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Dr. Andy Galpin

๐Ÿ‘ค Speaker
9972 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In fact, over 50% of the athletes in these studies had an omega-3 index of less than 4%. So it is really, really, really common in our athletes to see omega-3 status being really insufficient. And the same thing has happened in the general population. So you can 100% achieve enough for brain health through food if you'd like, you just need to make a considered effort for it.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

In fact, over 50% of the athletes in these studies had an omega-3 index of less than 4%. So it is really, really, really common in our athletes to see omega-3 status being really insufficient. And the same thing has happened in the general population. So you can 100% achieve enough for brain health through food if you'd like, you just need to make a considered effort for it.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And you can see and go back to hear the dosages. Or you can use supplements or a combination, but you absolutely want to make sure that you're doing this prophylactically as well as if you do experience an injury, getting right on the supplementation as quickly as you can. Next up is what's called vitamin B2 or riboflavin.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And you can see and go back to hear the dosages. Or you can use supplements or a combination, but you absolutely want to make sure that you're doing this prophylactically as well as if you do experience an injury, getting right on the supplementation as quickly as you can. Next up is what's called vitamin B2 or riboflavin.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

We're going into riboflavin next because it is a requirement for proper DHA utilization. Here's what I mean. There's some really nice studies showing that if you give people DHA, but they have insufficient B2, B6, B9, B12, and choline, they won't integrate that DHA into their brain.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

We're going into riboflavin next because it is a requirement for proper DHA utilization. Here's what I mean. There's some really nice studies showing that if you give people DHA, but they have insufficient B2, B6, B9, B12, and choline, they won't integrate that DHA into their brain.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So it's really, really hard technically to get the DHA to integrate into the phospholipid membrane without these B vitamins. And so part and parcel to our appropriate omega-3 status is making sure we're not vitamin B deficient. And specifically in this case, we're talking about riboflavin. So it is a coenzyme for ATP production. It's a part of many of our energy production cycles.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So it's really, really hard technically to get the DHA to integrate into the phospholipid membrane without these B vitamins. And so part and parcel to our appropriate omega-3 status is making sure we're not vitamin B deficient. And specifically in this case, we're talking about riboflavin. So it is a coenzyme for ATP production. It's a part of many of our energy production cycles.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

It's also highly responsible for glutathione. You'll hear me bring this up again, but glutathione is our chief endogenous antioxidant. It's the big whopper, okay? So going back to our problems associated with injury, Riboflavin is going to play a role in two of those ones, energy production, as well as inflammation or antioxidant capacity. So really helpful from that regard.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

It's also highly responsible for glutathione. You'll hear me bring this up again, but glutathione is our chief endogenous antioxidant. It's the big whopper, okay? So going back to our problems associated with injury, Riboflavin is going to play a role in two of those ones, energy production, as well as inflammation or antioxidant capacity. So really helpful from that regard.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Since we know TBI has metabolic problems, it makes sense that these B2 and other B vitamins are going to probably play an important role. The SOE on riboflavin is a three. Now, personally, that's enough for me to take action. You're welcome to choose your own level. I've actually not a score here, but I have utilized and will probably continue to utilize riboflavin for head-related injuries.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Since we know TBI has metabolic problems, it makes sense that these B2 and other B vitamins are going to probably play an important role. The SOE on riboflavin is a three. Now, personally, that's enough for me to take action. You're welcome to choose your own level. I've actually not a score here, but I have utilized and will probably continue to utilize riboflavin for head-related injuries.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's great data in rat studies that have shown riboflavin helps with some of the behavioral modification issues associated with downstream TBI problems. Humans, there's not that much research, candidly. Again, that's why it has an SOE score of 3, not 2 or 1. And what we do know is there's kind of two studies in particular that are classic, and they both used about 400 milligrams per day.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's great data in rat studies that have shown riboflavin helps with some of the behavioral modification issues associated with downstream TBI problems. Humans, there's not that much research, candidly. Again, that's why it has an SOE score of 3, not 2 or 1. And what we do know is there's kind of two studies in particular that are classic, and they both used about 400 milligrams per day.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

One of them is a bit older, 1998, I think it was published, and it was actually in migraines. And what it showed is that it was safe and well-tolerated. Now, interestingly, this was followed up in 2023, and they gave, again, 400 milligrams. I think they actually did it twice per day instead of once per day, starting 24 hours after injury.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

One of them is a bit older, 1998, I think it was published, and it was actually in migraines. And what it showed is that it was safe and well-tolerated. Now, interestingly, this was followed up in 2023, and they gave, again, 400 milligrams. I think they actually did it twice per day instead of once per day, starting 24 hours after injury.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

I think they had 50 plus people in the study and they're all about 20 years old. Now in that, they found a significant reduction in the number of days of recovery by about half. So the group that did not get the supplement, the typical recovery day was 22 days long. The supplement group, it was cut down to 10. So this was a very, very, very impressive result.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

I think they had 50 plus people in the study and they're all about 20 years old. Now in that, they found a significant reduction in the number of days of recovery by about half. So the group that did not get the supplement, the typical recovery day was 22 days long. The supplement group, it was cut down to 10. So this was a very, very, very impressive result.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And so it seems to be a somewhat high reward, low risk option. Additionally, the other B vitamins like B6 and B12 have probably more limited research, but they're really plausible. They're also really safe. They've been studied a lot in a lot of unhealthy or risky populations, and they just don't really have that many negative side effects. So sounds logical to try these ones.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And so it seems to be a somewhat high reward, low risk option. Additionally, the other B vitamins like B6 and B12 have probably more limited research, but they're really plausible. They're also really safe. They've been studied a lot in a lot of unhealthy or risky populations, and they just don't really have that many negative side effects. So sounds logical to try these ones.