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Dr. Andy Galpin

๐Ÿ‘ค Speaker
9972 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There is a little bit of work here, Particularly what I'm thinking of is some rat studies in cases of things like folate deficiency. When that happens, a little bit of a background there, when you are deficient in folate, you have higher levels of what's called homocysteine. Homocysteine is highly associated with additional oxidative stress and a whole host of other negative health cascades.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There is a little bit of work here, Particularly what I'm thinking of is some rat studies in cases of things like folate deficiency. When that happens, a little bit of a background there, when you are deficient in folate, you have higher levels of what's called homocysteine. Homocysteine is highly associated with additional oxidative stress and a whole host of other negative health cascades.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So really high homocysteine is bad news. Homocysteine is often also elevated when B vitamins are too low in general. That alone is associated with neuropathy of TBIs, brain atrophy, cognitive decline with aging, and so on and so forth. And so the clinical trials that have been done in this area where they combine these B vitamins and omega-3s have been shown to reduce homocysteine.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So really high homocysteine is bad news. Homocysteine is often also elevated when B vitamins are too low in general. That alone is associated with neuropathy of TBIs, brain atrophy, cognitive decline with aging, and so on and so forth. And so the clinical trials that have been done in this area where they combine these B vitamins and omega-3s have been shown to reduce homocysteine.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And that has then also been associated with a reduction in cognitive decline. So if you can, pay attention to all those B vitamins, try to get them as high as reasonable, or at least not in those danger areas. Take a look at homocysteine and pay attention to that. And if you do that, that will give those omega-3s a better chance to work more effectively, and you should be in a better spot.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And that has then also been associated with a reduction in cognitive decline. So if you can, pay attention to all those B vitamins, try to get them as high as reasonable, or at least not in those danger areas. Take a look at homocysteine and pay attention to that. And if you do that, that will give those omega-3s a better chance to work more effectively, and you should be in a better spot.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So what's riboflavin look like in terms of supplementation and food? one more time the dosages that have been studied for migraines and headaches and brain health and things like that are 400 milligrams per day one of the studies did that dosage once per day another did it twice per day but those are really really common now you can look all over the internet and you will generally find

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So what's riboflavin look like in terms of supplementation and food? one more time the dosages that have been studied for migraines and headaches and brain health and things like that are 400 milligrams per day one of the studies did that dosage once per day another did it twice per day but those are really really common now you can look all over the internet and you will generally find

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Every multivitamin has riboflavin, but it's not very much. So multivitamins are not going to be the place you can go to to get enough B2 for this issue. You're going to have to go to companies that make B2 specifically. And in terms of timing, again, you want to take this...

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Every multivitamin has riboflavin, but it's not very much. So multivitamins are not going to be the place you can go to to get enough B2 for this issue. You're going to have to go to companies that make B2 specifically. And in terms of timing, again, you want to take this...

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

after your brain injuries, certainly, but the better option is just to make sure your B status is high enough prior to going in, okay? But if you didn't do that or don't know, you'd want to take this post-injury. Time of day doesn't matter at all. Some people will feel a little bit of an energetic effect, so perhaps earlier in the morning. Others don't, but you might want to consider that.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

after your brain injuries, certainly, but the better option is just to make sure your B status is high enough prior to going in, okay? But if you didn't do that or don't know, you'd want to take this post-injury. Time of day doesn't matter at all. Some people will feel a little bit of an energetic effect, so perhaps earlier in the morning. Others don't, but you might want to consider that.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

I'm not aware of any risks associated with it, Obviously, everything has some risk of some dosage in some people. But for the most part, there's very little harm here. B vitamins typically don't have many issues if you overconsume them, outside of perhaps wasting your money, I guess, if you want to think about it that way. But there's really very little consequences at reasonable dosages.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

I'm not aware of any risks associated with it, Obviously, everything has some risk of some dosage in some people. But for the most part, there's very little harm here. B vitamins typically don't have many issues if you overconsume them, outside of perhaps wasting your money, I guess, if you want to think about it that way. But there's really very little consequences at reasonable dosages.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So you should be okay there. If you want to get this from whole food sources, this is where things like liver come in handy or fortified cereals. Whey protein actually has a decent amount. Beef liver specifically has 3.4 milligrams of riboflavin per 100 grams. Whey protein is about half that. I think it's about two actually. So it's not a terrible source.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So you should be okay there. If you want to get this from whole food sources, this is where things like liver come in handy or fortified cereals. Whey protein actually has a decent amount. Beef liver specifically has 3.4 milligrams of riboflavin per 100 grams. Whey protein is about half that. I think it's about two actually. So it's not a terrible source.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So you can run the math very similar to how we just did it before. I won't drag you through it again. But if you have to eat something like 15 times-ish, the amount of the serving size I just listed, to get to that 400 milligrams per day, that's going to be a pound, a pound and a half. Sorry, a kilo or a kilo and a half of beef liver per day.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So you can run the math very similar to how we just did it before. I won't drag you through it again. But if you have to eat something like 15 times-ish, the amount of the serving size I just listed, to get to that 400 milligrams per day, that's going to be a pound, a pound and a half. Sorry, a kilo or a kilo and a half of beef liver per day.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So again, theoretically possible, but just pretty unlikely or pretty unrealistic for most people to get these at this dosage through just food. Now remember, these are not daily amounts you have to take. We're talking about the dosages specifically for a brain injury. And so it's actually not that crazy to think you're taking it if you've experienced something like this.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So again, theoretically possible, but just pretty unlikely or pretty unrealistic for most people to get these at this dosage through just food. Now remember, these are not daily amounts you have to take. We're talking about the dosages specifically for a brain injury. And so it's actually not that crazy to think you're taking it if you've experienced something like this.