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Dr. Andy Galpin

๐Ÿ‘ค Speaker
9972 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And so you can take whatever form sits best with you. The obvious risks associated with magnesium are the GI distress. Bisglycinate, malate, threonate are generally pretty well handled. And so you shouldn't have too many issues with it. If you want to get it strictly from food, you're looking now at things like pumpkin seeds, chia seeds, almonds, and spinach.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

And so you can take whatever form sits best with you. The obvious risks associated with magnesium are the GI distress. Bisglycinate, malate, threonate are generally pretty well handled. And so you shouldn't have too many issues with it. If you want to get it strictly from food, you're looking now at things like pumpkin seeds, chia seeds, almonds, and spinach.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Typically, I think pumpkin seeds are about the highest you'll find. They've got around 200 milligrams of magnesium per 100 grams roasted. Again, you can do some math there and realize, all right, that's at least 200 grams of roasted pumpkin seeds I'd have to get to get to my 400 milligrams, which is honestly quite a lot. Not impossible.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Typically, I think pumpkin seeds are about the highest you'll find. They've got around 200 milligrams of magnesium per 100 grams roasted. Again, you can do some math there and realize, all right, that's at least 200 grams of roasted pumpkin seeds I'd have to get to get to my 400 milligrams, which is honestly quite a lot. Not impossible.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Some people eat tons of almonds and spinach and things like that, especially vegetarians and vegans. But it is quite a bit, given how cheap, effective, and easy to handle, and how many other things are benefited. Magnesium is a supplement. We use it pretty commonly. Our final food item to discuss is what's called anthocyanins. Now, these come almost always from blueberries.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Some people eat tons of almonds and spinach and things like that, especially vegetarians and vegans. But it is quite a bit, given how cheap, effective, and easy to handle, and how many other things are benefited. Magnesium is a supplement. We use it pretty commonly. Our final food item to discuss is what's called anthocyanins. Now, these come almost always from blueberries.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So, henceforward, I'll call these blueberry anthos. That's how I refer to it. Now, these are phytochemicals in the flavonoid family. There's over 700 known anthocyanins. and we're honestly basically just learning about this stuff. So we have a ton of improvements needed, a ton more analysis and understanding of mechanisms and so on and so forth, but there's enough here to go on at this point.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

So, henceforward, I'll call these blueberry anthos. That's how I refer to it. Now, these are phytochemicals in the flavonoid family. There's over 700 known anthocyanins. and we're honestly basically just learning about this stuff. So we have a ton of improvements needed, a ton more analysis and understanding of mechanisms and so on and so forth, but there's enough here to go on at this point.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

We know that anthos are involved in cardiovascular disease, metabolic syndrome, type 2 diabetes, cancers, visions, skin health, inflammation, neurodegenerative disorders, and probably 50 more things. Really ubiquitous, really robust, and critical to a bunch of human functions. TBI specifically?

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

We know that anthos are involved in cardiovascular disease, metabolic syndrome, type 2 diabetes, cancers, visions, skin health, inflammation, neurodegenerative disorders, and probably 50 more things. Really ubiquitous, really robust, and critical to a bunch of human functions. TBI specifically?

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Animal research here, blueberry supplements or blueberry extracts post-injury have been shown to improve what's called brain-derived neurotropic factor, or what you may have heard of as BDNF, which is inversely correlated with indirect markers of memory, performance, and cognition. Now, a similar study has found that blueberries also protect against oxidative stress, which makes a ton of sense.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

Animal research here, blueberry supplements or blueberry extracts post-injury have been shown to improve what's called brain-derived neurotropic factor, or what you may have heard of as BDNF, which is inversely correlated with indirect markers of memory, performance, and cognition. Now, a similar study has found that blueberries also protect against oxidative stress, which makes a ton of sense.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

You've all probably heard about the antioxidant properties associated with blueberries and blueberry extracts. So this is no surprise for most people. The SOE for Anthos is a three. And in terms of human data, I don't think there's a single RCT, randomized controlled trial, that exists for blueberries and TBI at this point.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

You've all probably heard about the antioxidant properties associated with blueberries and blueberry extracts. So this is no surprise for most people. The SOE for Anthos is a three. And in terms of human data, I don't think there's a single RCT, randomized controlled trial, that exists for blueberries and TBI at this point.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

That said, there have been studies, many RCTs, some in fact that range from developmental to aging to clinical populations, on brain health. And so this is a classic example of where we can infer some things from general brain health over to TBI at a pretty low risk, high reward possibility. The collective evidence indicates that it does help with attention, memory, executive function.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

That said, there have been studies, many RCTs, some in fact that range from developmental to aging to clinical populations, on brain health. And so this is a classic example of where we can infer some things from general brain health over to TBI at a pretty low risk, high reward possibility. The collective evidence indicates that it does help with attention, memory, executive function.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's a lot of evidence. Specifically, we use a handful of papers that have been done looking at blueberries prior to golf and enhancing brain performance in sport context. So there's a lot out there. We know it works, but we also know we're missing a lot of the details because of what I just described earlier. It's pretty new. A couple of examples.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

There's a lot of evidence. Specifically, we use a handful of papers that have been done looking at blueberries prior to golf and enhancing brain performance in sport context. So there's a lot out there. We know it works, but we also know we're missing a lot of the details because of what I just described earlier. It's pretty new. A couple of examples.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

One study in kids in particular looked at 15 or 30 grams of freeze-dried wild blueberries and saw significant improvements in cognitive function in a dose-dependent fashion. The more blueberries, the better.

Huberman Lab
Perform with Dr. Andy Galpin: Nutrition to Support Brain Health & Offset Brain Injuries

One study in kids in particular looked at 15 or 30 grams of freeze-dried wild blueberries and saw significant improvements in cognitive function in a dose-dependent fashion. The more blueberries, the better.