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Dr. Andy Galpin

๐Ÿ‘ค Speaker
9972 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

To give you a little bit of concept of how big that is, number one, you can see that with the naked eye.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

I could pull up in my laboratory a pair of tweezers, a single muscle fiber from a human.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

I could hold it up right now and on this camera, you would absolutely be able to see that both on camera as well as with your naked eye if you were within even five to 10 feet of me.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

In terms of cross-sectional area, you're looking at something like 4,000 to 5,000 micrometers squared, which a little bit of context there.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

One time, actually, I had a long-established power lifter as well as anabolic steroid user in my lab, and we biopsied this individual, and his muscle fibers were closer to 9,000 micrometers.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

And the closest equivalent we found there was actually a rhinoceros.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

So muscle fibers are not only large in terms of biology, but the ability to gain size is extraordinary.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

As again, I said earlier, one of the things that makes skeletal muscle in humans especially unique is the ability to respond and adapt based on stimuli.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

In fact, it seems to be quite unending.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

Now we'll come back and talk about muscle fibers size and how to develop it a little bit later.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

But getting back to this idea of fiber number, as I mentioned, it's thought to be fairly fixed once you reach adulthood.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

However, it is extremely clear that this number will go down with aging.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

unless you do something proactively to prevent that.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

It's actually also very clear that this number can increase with anabolic steroid use.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

Now, this concept of growing new muscle fibers is called hyperplasia and something that has been hotly contested in the exercise physiology world for many, many decades.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

Now, I will give you a little bit of a behind the scenes here.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

I personally am always been a big believer in hyperplasia happening.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

I won't say the science is strongly in my support, but it's been one of the passion projects that I'm not going to give up on.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

Now, what I'm really talking about here is there's no question whatsoever that new cells can grow.

Huberman Lab
Perform with Dr. Andy Galpin: Why Muscle Matters & How to Build It

That's not really the debate.