Dr. Aseem Malhotra

So myself and two cardiologists did a systematic review of the totality of drug industry sponsored trials, by the way, and some diet trials, but many drug industry sponsored trials, all of the randomized control trials. on cholesterol-lowering drugs, statins, PCK9, blah, blah, blah. Was there a clear relationship as you lowered LDL in low-risk and high-risk patients, Mark? Okay. Over 30 studies.

So myself and two cardiologists did a systematic review of the totality of drug industry sponsored trials, by the way, and some diet trials, but many drug industry sponsored trials, all of the randomized control trials. on cholesterol-lowering drugs, statins, PCK9, blah, blah, blah. Was there a clear relationship as you lowered LDL in low-risk and high-risk patients, Mark? Okay. Over 30 studies.

Yeah. Was there a relationship with lowering LDL and preventing cardiovascular events? No, even in high risk patients, even in high risk, it's nonsense. It's nonsense. So the question then is, so does that mean stat? But then I said, well, of course statins have a role.

Yeah. Was there a relationship with lowering LDL and preventing cardiovascular events? No, even in high risk patients, even in high risk, it's nonsense. It's nonsense. So the question then is, so does that mean stat? But then I said, well, of course statins have a role.

Yeah. Was there a relationship with lowering LDL and preventing cardiovascular events? No, even in high risk patients, even in high risk, it's nonsense. It's nonsense. So the question then is, so does that mean stat? But then I said, well, of course statins have a role.

They do have a benefit from the, from the RCT data, which is small because I knew already they're anti-inflammatory and anti-clotting. So it's nothing in my view, listen, I could be proven wrong here, but the evidence at the moment looks very clear that there is no consistent relationship, right? It's definitely not a clear relationship.

They do have a benefit from the, from the RCT data, which is small because I knew already they're anti-inflammatory and anti-clotting. So it's nothing in my view, listen, I could be proven wrong here, but the evidence at the moment looks very clear that there is no consistent relationship, right? It's definitely not a clear relationship.

They do have a benefit from the, from the RCT data, which is small because I knew already they're anti-inflammatory and anti-clotting. So it's nothing in my view, listen, I could be proven wrong here, but the evidence at the moment looks very clear that there is no consistent relationship, right? It's definitely not a clear relationship.

So even if it's a weak relationship, Mark, let's just argument say, let's say there is a weak benefit in lowering LDL. What else is going on? And what else are you ignoring, right? What else does statins do? They cause insulin resistance. Say one in a hundred people get type two diabetes because of statins. One in two. One in a hundred. One in a hundred. Yeah, one in a hundred.

So even if it's a weak relationship, Mark, let's just argument say, let's say there is a weak benefit in lowering LDL. What else is going on? And what else are you ignoring, right? What else does statins do? They cause insulin resistance. Say one in a hundred people get type two diabetes because of statins. One in two. One in a hundred. One in a hundred. Yeah, one in a hundred.

So even if it's a weak relationship, Mark, let's just argument say, let's say there is a weak benefit in lowering LDL. What else is going on? And what else are you ignoring, right? What else does statins do? They cause insulin resistance. Say one in a hundred people get type two diabetes because of statins. One in two. One in a hundred. One in a hundred. Yeah, one in a hundred.

So about one to 2%, but one in a hundred. Some studies say one in 50, right? We'll get type two diabetes because of the statin. Probably reversible still, but not ideal, right? If you're on a statin drug. The second thing is, look at the whole patient coming in. We have the illusion of protection. We have patients I used to see coming in and they thought, my cholesterol is low.

So about one to 2%, but one in a hundred. Some studies say one in 50, right? We'll get type two diabetes because of the statin. Probably reversible still, but not ideal, right? If you're on a statin drug. The second thing is, look at the whole patient coming in. We have the illusion of protection. We have patients I used to see coming in and they thought, my cholesterol is low.

So about one to 2%, but one in a hundred. Some studies say one in 50, right? We'll get type two diabetes because of the statin. Probably reversible still, but not ideal, right? If you're on a statin drug. The second thing is, look at the whole patient coming in. We have the illusion of protection. We have patients I used to see coming in and they thought, my cholesterol is low.

I can go and eat at McDonald's. It's fine. And they're getting more and more overweight, more inter-resistant. They're increasing their cardiovascular risk. They're not told the statin is going to give them a 1% benefit, i.e. more likely than not, they're not going to benefit.

I can go and eat at McDonald's. It's fine. And they're getting more and more overweight, more inter-resistant. They're increasing their cardiovascular risk. They're not told the statin is going to give them a 1% benefit, i.e. more likely than not, they're not going to benefit.

I can go and eat at McDonald's. It's fine. And they're getting more and more overweight, more inter-resistant. They're increasing their cardiovascular risk. They're not told the statin is going to give them a 1% benefit, i.e. more likely than not, they're not going to benefit.

So you could imagine that concept that the overall net effect of the way that statins are prescribed and the dogma around them, in my view, has been negative and has actually been one of the main reasons why we have got this pandemic of chronic disease.

So you could imagine that concept that the overall net effect of the way that statins are prescribed and the dogma around them, in my view, has been negative and has actually been one of the main reasons why we have got this pandemic of chronic disease.

So you could imagine that concept that the overall net effect of the way that statins are prescribed and the dogma around them, in my view, has been negative and has actually been one of the main reasons why we have got this pandemic of chronic disease.