Dr. Aseem Malhotra

Well, something else to throw into the picture, right? So you could make the argument, okay, Dr. Malhotra, you're saying there's no consistent relationship. There may be a benefit. Why not just lower your LDL? Okay, so 2016. And the reason we did this, me and a number of international scientists looked at, we decided to do a systematic review of observational data looking at people over 60.

Well, something else to throw into the picture, right? So you could make the argument, okay, Dr. Malhotra, you're saying there's no consistent relationship. There may be a benefit. Why not just lower your LDL? Okay, so 2016. And the reason we did this, me and a number of international scientists looked at, we decided to do a systematic review of observational data looking at people over 60.

Well, something else to throw into the picture, right? So you could make the argument, okay, Dr. Malhotra, you're saying there's no consistent relationship. There may be a benefit. Why not just lower your LDL? Okay, so 2016. And the reason we did this, me and a number of international scientists looked at, we decided to do a systematic review of observational data looking at people over 60.

Was there a relationship with LDL cholesterol and heart disease? And the reason we did this, by the way, is another thing that was interesting from framing, which wasn't well publicized, is that when, after people hit 50 years old, as their cholesterol dropped, their mortality increased.

Was there a relationship with LDL cholesterol and heart disease? And the reason we did this, by the way, is another thing that was interesting from framing, which wasn't well publicized, is that when, after people hit 50 years old, as their cholesterol dropped, their mortality increased.

Was there a relationship with LDL cholesterol and heart disease? And the reason we did this, by the way, is another thing that was interesting from framing, which wasn't well publicized, is that when, after people hit 50 years old, as their cholesterol dropped, their mortality increased.

So we thought, okay, is there something, you know, because for it to be a risk factor for heart disease, it should be consistent really across all age groups and both sexes, right? For mortality. For mortality, yeah. But even for heart disease as well, right? That's a good point.

So we thought, okay, is there something, you know, because for it to be a risk factor for heart disease, it should be consistent really across all age groups and both sexes, right? For mortality. For mortality, yeah. But even for heart disease as well, right? That's a good point.

So we thought, okay, is there something, you know, because for it to be a risk factor for heart disease, it should be consistent really across all age groups and both sexes, right? For mortality. For mortality, yeah. But even for heart disease as well, right? That's a good point.

So we looked at, was there first of all any association, if you're over 60, with LDL cholesterol and heart disease, right? We found none. Okay, interesting. But what was surprising was there was an inverse association with LDL cholesterol and all-cause mortality. In other ways, statistically, if you're over 60, the higher LDL, the less likely you are to die. So what's the reasoning for that?

So we looked at, was there first of all any association, if you're over 60, with LDL cholesterol and heart disease, right? We found none. Okay, interesting. But what was surprising was there was an inverse association with LDL cholesterol and all-cause mortality. In other ways, statistically, if you're over 60, the higher LDL, the less likely you are to die. So what's the reasoning for that?

So we looked at, was there first of all any association, if you're over 60, with LDL cholesterol and heart disease, right? We found none. Okay, interesting. But what was surprising was there was an inverse association with LDL cholesterol and all-cause mortality. In other ways, statistically, if you're over 60, the higher LDL, the less likely you are to die. So what's the reasoning for that?

Well, something that's been forgotten or missed or not discussed. Cholesterol has a very vital role in many functions in the body, including the brain, hormone production, but also the immune system. Mm-hmm. And it's likely that that's where the protective benefit comes because older people are more vulnerable to dying from infections.

Well, something that's been forgotten or missed or not discussed. Cholesterol has a very vital role in many functions in the body, including the brain, hormone production, but also the immune system. Mm-hmm. And it's likely that that's where the protective benefit comes because older people are more vulnerable to dying from infections.

Well, something that's been forgotten or missed or not discussed. Cholesterol has a very vital role in many functions in the body, including the brain, hormone production, but also the immune system. Mm-hmm. And it's likely that that's where the protective benefit comes because older people are more vulnerable to dying from infections.

And we also know there is an association, I'll use this word, an association, right? I can't say it's definitely causal, between low cholesterol and cancer. Again, it's probably related to the immune system.

And we also know there is an association, I'll use this word, an association, right? I can't say it's definitely causal, between low cholesterol and cancer. Again, it's probably related to the immune system.

And we also know there is an association, I'll use this word, an association, right? I can't say it's definitely causal, between low cholesterol and cancer. Again, it's probably related to the immune system.

So let me push back on that. So we counted for that. And we found actually, no, when you count time lag, you go back 5 or 10 years. No, it's not. That does happen. But no, independently, it does seem to be an issue.

So let me push back on that. So we counted for that. And we found actually, no, when you count time lag, you go back 5 or 10 years. No, it's not. That does happen. But no, independently, it does seem to be an issue.