Dr. Ben Bikman

So that's a couple mechanisms among others, including mitochondrial biogenesis and a little bit of uncoupling, where apple cider vinegar is one of my favorites, where if you take a couple tablespoons before your most starchy meal, you absolutely could compare the glucose curve from one day to the next, and you'll see that it's significantly lower with just that tart little bit of drinking.

I think acetic acid, I know beta-hydroxybutyrate

One of the ways that main ketone, not that we've talked about ketones, but some of my work is on ketones.

I've wondered in the past, the ketone is unique because on one hand, it's a nutrient, it's a calorie to be burned.

But at the other hand, it's a signaling molecule.

And it is known to elicit some of its signaling like anti-inflammatory effects and antioxidant effects.

Part of it is through changes elicited because of a G protein coupled receptor where it does have a cell surface receptor that it will activate.

I don't know the degree to which acetic acid may do the same thing, but with regards to beta-hydroxybutyrate,

Even exogenous ketones, that wasn't one you mentioned, but there are increasing studies showing that you can have... There was just a study in women with PCOS.

The only intervention was to give them exogenous ketones.

And...

Every outcome related to metabolic markers and PCOS got better.

And the only change was the supplementation with exogenous ketones.

I don't know that that was an effect of the bioenergetics of the ketone.

It was probably more of the signaling effect.

And so that would be another thing if a person's becoming increasingly curious about ketones.

And that's not without justification.

The evidence supporting the value of ketones is growing and growing rapidly.

quickly, and it ought to.

I have never in the past wanted to be seen as a drum-beating advocate of a ketogenic diet, simply knowing that that's not everyone's cup of tea.