Dr. Ben Bikman

And to me, that has a tremendous power.

That's a reason to focus on that disorder.

Yeah, that's a great question.

In fact, that's a big question.

And I already am too long-winded with my answers, so I'm going to try to be concise here.

I look at the origins of insulin resistance as being one of two origins, where you have what I call fast insulin resistance and then slow insulin resistance.

And what you're touching on is the slow insulin resistance, which I'll come to in just a second.

Within the fast insulin resistance side, there are three what I call primary stimuli that

that in humans have been confirmed and in rodents and in isolated cell cultures that can cause insulin resistance quickly, like within hours.

But at the same time, if the stimulus is removed, the insulin resistance is resolved in short order.

And that is stress.

So elevated stress hormones, whether it's cortisol or epinephrine, adrenaline, will cause acute insulin resistance in humans.

as that stimulus goes away, the problem resolves.

Next is inflammation.

If you increase the levels of inflammatory cytokines in cells or rodents or humans, they will be insulin resistant very quickly.

In fact, people wearing CGMs may notice this

that the CGM may reveal that they're starting to get a cold or a flu because they notice that their glucose levels, they're having a much harder time controlling them, even though their habits haven't changed.

That's often a sign of inflammation.

But even with autoimmune diseases, where you have people where the autoimmune disease will ebb and flow, so too will the insulin resistance.

It will track very well with how active the disease is.