Dr. Ben Bikman

And that it's once the fat cells start to reach a point of maximum dimension, and by that I mean every individual fat cell is getting too big, now the body has reached its threshold. And if insulin is attempting to still tell the body to store energy, now you have a war, a metabolic mutiny, where the fat cell starts to rebel. So we gain fat through two different processes.

And that it's once the fat cells start to reach a point of maximum dimension, and by that I mean every individual fat cell is getting too big, now the body has reached its threshold. And if insulin is attempting to still tell the body to store energy, now you have a war, a metabolic mutiny, where the fat cell starts to rebel. So we gain fat through two different processes.

And that it's once the fat cells start to reach a point of maximum dimension, and by that I mean every individual fat cell is getting too big, now the body has reached its threshold. And if insulin is attempting to still tell the body to store energy, now you have a war, a metabolic mutiny, where the fat cell starts to rebel. So we gain fat through two different processes.

You know, you have two buddies, you have Drew and Ben, we're going on vacation, hanging out together, and we both come back from our trip 10 pounds fatter.

You know, you have two buddies, you have Drew and Ben, we're going on vacation, hanging out together, and we both come back from our trip 10 pounds fatter.

You know, you have two buddies, you have Drew and Ben, we're going on vacation, hanging out together, and we both come back from our trip 10 pounds fatter.

Because of our unique ethnicity and the genetics that come with that, some of my weight gain potentially would have happened through some modest degree of hyperplasia, where when my fat cells started to get a little big, I would simply create some new fat cells. Whereas Drew, with South Asian ethnicity, your fat cells have a very limited potential for hyperplasia.

Because of our unique ethnicity and the genetics that come with that, some of my weight gain potentially would have happened through some modest degree of hyperplasia, where when my fat cells started to get a little big, I would simply create some new fat cells. Whereas Drew, with South Asian ethnicity, your fat cells have a very limited potential for hyperplasia.

Because of our unique ethnicity and the genetics that come with that, some of my weight gain potentially would have happened through some modest degree of hyperplasia, where when my fat cells started to get a little big, I would simply create some new fat cells. Whereas Drew, with South Asian ethnicity, your fat cells have a very limited potential for hyperplasia.

In other words, you're not going to multiply your fat cells. The number of fat cells is pretty set. So then what happens is the fat cells each just get bigger and bigger and bigger. So each fat cell is carrying a bigger metabolic load than it would normally.

In other words, you're not going to multiply your fat cells. The number of fat cells is pretty set. So then what happens is the fat cells each just get bigger and bigger and bigger. So each fat cell is carrying a bigger metabolic load than it would normally.

In other words, you're not going to multiply your fat cells. The number of fat cells is pretty set. So then what happens is the fat cells each just get bigger and bigger and bigger. So each fat cell is carrying a bigger metabolic load than it would normally.

Whereas again, in another body that can undergo hyperplasia, the fat cell gets a little big and it recruits a new fat cell, which gets a little big. So more important than the mass of fat we have on our body is the size of each individual fat cell. which of course is impossible to measure outside of a lab. We can do that thing here in my lab by taking biopsies of people's fat tissue.

Whereas again, in another body that can undergo hyperplasia, the fat cell gets a little big and it recruits a new fat cell, which gets a little big. So more important than the mass of fat we have on our body is the size of each individual fat cell. which of course is impossible to measure outside of a lab. We can do that thing here in my lab by taking biopsies of people's fat tissue.

Whereas again, in another body that can undergo hyperplasia, the fat cell gets a little big and it recruits a new fat cell, which gets a little big. So more important than the mass of fat we have on our body is the size of each individual fat cell. which of course is impossible to measure outside of a lab. We can do that thing here in my lab by taking biopsies of people's fat tissue.

But even still, it's not something you're gonna really do. That's why you start to look at these other markers that we mentioned. But to sort of wrap through this idea quickly, when the fat cell gets really, really big, two problems start to happen.

But even still, it's not something you're gonna really do. That's why you start to look at these other markers that we mentioned. But to sort of wrap through this idea quickly, when the fat cell gets really, really big, two problems start to happen.

But even still, it's not something you're gonna really do. That's why you start to look at these other markers that we mentioned. But to sort of wrap through this idea quickly, when the fat cell gets really, really big, two problems start to happen.

One, it starts to reach a point of maximum dimension that it can't grow anymore, otherwise the cell membrane starts to lose its integrity and literally start to pop, which would be a very messy inflammatory process. And at the second, the fat cell, as it's swollen up to 10 or 20 times bigger than it used to be, is now suffocating. It's getting pushed too far from capillaries.

One, it starts to reach a point of maximum dimension that it can't grow anymore, otherwise the cell membrane starts to lose its integrity and literally start to pop, which would be a very messy inflammatory process. And at the second, the fat cell, as it's swollen up to 10 or 20 times bigger than it used to be, is now suffocating. It's getting pushed too far from capillaries.