Dr. Casey Means

So no one has basically described this better than you.

I feel like you're on your platform.

But I think about it very, very simply.

Throughout human history, humans have really in so many different parts of the world been exposed to hugely fluctuating temperatures.

Like if you look at the Sahara Desert or like a regular day in Colorado, it's like you can go from – let's talk about the Sahara Desert.

You can go from 30 degrees to 110 degrees in the span of one day.

And like even the concept of indoors is like a relatively –

new concept in human history, four walls, insulation, then central heating and cooling, that's like the last 50, 75 years in most homes.

And so this idea, our cells have evolved to respond to big swings in temperature that very recently we have totally pulled away.

And I think that...

When I think about the mitochondria and increasing their capacity, I'm thinking about, well, how do I use different energetic signals in my environment to essentially get the mitochondria to do better work?

And we can think about all the different types of energy that we're exposed to, solar energy, thermal energy, acoustic energy, mechanical energy.

you know food energy like there's there's that's basically what our environment is right and thermal energy is a big one of those we can speak to our mitochondria with the language of thermal energy and say hey it's cold outside we need you to print more of yourselves or work harder such that we can create heat inside the body to respond to this stimulus and so that's kind of the framing that i use for it and like i

This data is hard to know if it's totally accurate, but our population is cooling.

And I think it was data out of Stanford, actually, that was showing that our temperature has gone down like 2% or something like that in the last 100 years.

And that fundamentally is mitochondria not...

working as well as they should.

Research has shown we're making less ATP in a lot of our cells and that's, you know, function of mitochondrial dysfunction.

One fun fact, I don't know if you knew this, but, uh, the body makes about 88 pounds of ATP per day for like the average American.

So we're constantly making it and we're constantly recycling it in this, like, you know, like basically