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Dr. Casey Means

๐Ÿ‘ค Speaker
1139 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So releases it almost as a neurotransmitter, a purogenic neurotransmitter that massively activates the immune system to come and help.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

But the immune system comes and is like, not much we can do for you here.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

Because the problem is not something that the immune system can help with, like grabbing a bacteria and lysing it or taking care of some cells infected with the virus.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

The problem is outside the body.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

It's the environment.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So you end up getting this tornado of dysfunction, of mitochondrial dysfunction caused by the environment, leading to the cell danger response, which leads to innate immunity.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

And then on top of this, you get the oxae of stress, which is the third piece of the trifecta, which is essentially these mitochondria trying so hard to do their work, but they're not working properly.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So they create damaging metabolic byproducts called oxae of stress, free radicals that cause more damage.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So this is happening in the nose.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

It's happening all over the American body because of our environment.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So you've got these tornadoes of interrelated physiology of mitochondrial dysfunction all

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

chronic inflammation, oxidative stress, which if you start going to the research as a clinician who's focused on symptoms and confusing those for the disease and look at what's the pathophysiology of arthritis?

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

What's the pathophysiology of Alzheimer's dementia?

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

What's the pathophysiology of type 2 diabetes, obesity, fatty liver disease, polycystic ovarian syndrome, erectile dysfunction?

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

it all traces back to this trifecta that no medication or surgery, you obviously can't operate on oxidative stress, you can operate on the downstream symptoms.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

So that's the real secret that I really feel like we need to reorient the healthcare system around since 90% of healthcare costs

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

go towards treating the downstream symptoms of these and for every marginal dollar we're spending on treating symptoms we're getting the rates are going up because they're doing nothing to actually affect that trifecta but to really make it simple

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

I like to think of this trifecta of what I call trifecta of bad energy, trifecta underlying metabolic dysfunction of chronic inflammation, mitochondrial dysfunction, oxidative stress as chronic inflammation is biochemical fear.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

It's response to a threat.

Huberman Lab
Dr. Casey Means: Transform Your Health by Improving Metabolism, Hormone & Blood Sugar Regulation

Mitochondrial dysfunction is kind of like rolling blackouts.