Dr. Chris Palmer
๐ค PersonAppearances Over Time
Podcast Appearances
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of hyper stimulating their metabolic rate and then trying to suppress that hyper stimulation with sedatives so that they can sleep or calm down and then they're just but they're destroying their metabolic health and does that really play out like and is that you know some will say well chris that's just one of myriad things that they're doing to their cells sure
of hyper stimulating their metabolic rate and then trying to suppress that hyper stimulation with sedatives so that they can sleep or calm down and then they're just but they're destroying their metabolic health and does that really play out like and is that you know some will say well chris that's just one of myriad things that they're doing to their cells sure
of hyper stimulating their metabolic rate and then trying to suppress that hyper stimulation with sedatives so that they can sleep or calm down and then they're just but they're destroying their metabolic health and does that really play out like and is that you know some will say well chris that's just one of myriad things that they're doing to their cells sure
But does it play out in diseases that we think of as metabolic diseases? Absolutely. Type 2 diabetes, yes. Cardiovascular disease, 100%. Premature mortality, yeah. It's kind of like the elephant in the room that we have just failed to look at because we've been so splintered. No, it's biological. No, it's psychological. No, it's social. It's like, it's all of them.
But does it play out in diseases that we think of as metabolic diseases? Absolutely. Type 2 diabetes, yes. Cardiovascular disease, 100%. Premature mortality, yeah. It's kind of like the elephant in the room that we have just failed to look at because we've been so splintered. No, it's biological. No, it's psychological. No, it's social. It's like, it's all of them.
But does it play out in diseases that we think of as metabolic diseases? Absolutely. Type 2 diabetes, yes. Cardiovascular disease, 100%. Premature mortality, yeah. It's kind of like the elephant in the room that we have just failed to look at because we've been so splintered. No, it's biological. No, it's psychological. No, it's social. It's like, it's all of them.
Let's look at the elephant that comprises all of them.
Let's look at the elephant that comprises all of them.
Let's look at the elephant that comprises all of them.
There are other things, but I actually do think that's a... It's not just the number and density of mitochondria, but it's the health of mitochondria. Because unfortunately... You know, our cells have a process for getting rid of defective mitochondria. It's part of autophagy.
There are other things, but I actually do think that's a... It's not just the number and density of mitochondria, but it's the health of mitochondria. Because unfortunately... You know, our cells have a process for getting rid of defective mitochondria. It's part of autophagy.
There are other things, but I actually do think that's a... It's not just the number and density of mitochondria, but it's the health of mitochondria. Because unfortunately... You know, our cells have a process for getting rid of defective mitochondria. It's part of autophagy.
There's a sub kind of category called mitophagy in which defective mitochondria should be shuttled to lysosomes or shuttled out of cells. Recent paper actually found that microglia in the brain, again, send out these nanotunnels to astrocytes and collect defective mitochondria from the neuron and then take care of the disposal process for that neuron. We are so cool.
There's a sub kind of category called mitophagy in which defective mitochondria should be shuttled to lysosomes or shuttled out of cells. Recent paper actually found that microglia in the brain, again, send out these nanotunnels to astrocytes and collect defective mitochondria from the neuron and then take care of the disposal process for that neuron. We are so cool.
There's a sub kind of category called mitophagy in which defective mitochondria should be shuttled to lysosomes or shuttled out of cells. Recent paper actually found that microglia in the brain, again, send out these nanotunnels to astrocytes and collect defective mitochondria from the neuron and then take care of the disposal process for that neuron. We are so cool.
And that when you inhibit that, it appears to increase and accelerate neurodegeneration. And when you enhance that, it appears to improve or reduce neurodegeneration. But I think it is. I think children have more energy because they have healthier metabolism, healthier mitochondrial function. And when we look at, again, is there evidence for that? There's overwhelming evidence for that.
And that when you inhibit that, it appears to increase and accelerate neurodegeneration. And when you enhance that, it appears to improve or reduce neurodegeneration. But I think it is. I think children have more energy because they have healthier metabolism, healthier mitochondrial function. And when we look at, again, is there evidence for that? There's overwhelming evidence for that.
And that when you inhibit that, it appears to increase and accelerate neurodegeneration. And when you enhance that, it appears to improve or reduce neurodegeneration. But I think it is. I think children have more energy because they have healthier metabolism, healthier mitochondrial function. And when we look at, again, is there evidence for that? There's overwhelming evidence for that.