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Dr. Craig Koniver

👤 Person
906 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

One of those intermediate products, and the main one is something called NADH. That NADH is then shuttled to the mitochondrial membrane for, you know, this is the magic where we make the most ATP, and there's five different hubs, or we call cytochromes, right? And this is how I think about it, because I just like to simplify. Cytochrome one is where we use NADH.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

One of those intermediate products, and the main one is something called NADH. That NADH is then shuttled to the mitochondrial membrane for, you know, this is the magic where we make the most ATP, and there's five different hubs, or we call cytochromes, right? And this is how I think about it, because I just like to simplify. Cytochrome one is where we use NADH.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

One of those intermediate products, and the main one is something called NADH. That NADH is then shuttled to the mitochondrial membrane for, you know, this is the magic where we make the most ATP, and there's five different hubs, or we call cytochromes, right? And this is how I think about it, because I just like to simplify. Cytochrome one is where we use NADH.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what the different hubs are doing is we're exchanging electrons for protons. And that's a kind of an electrical process. We're exchanging electrons for protons, going down the assembly line to eventually turn this wheel, the ATPase wheel, to make ATP. The way I understand it is the five different hubs, different nutrients hit them. So cytochrome 1 is NAD.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what the different hubs are doing is we're exchanging electrons for protons. And that's a kind of an electrical process. We're exchanging electrons for protons, going down the assembly line to eventually turn this wheel, the ATPase wheel, to make ATP. The way I understand it is the five different hubs, different nutrients hit them. So cytochrome 1 is NAD.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And what the different hubs are doing is we're exchanging electrons for protons. And that's a kind of an electrical process. We're exchanging electrons for protons, going down the assembly line to eventually turn this wheel, the ATPase wheel, to make ATP. The way I understand it is the five different hubs, different nutrients hit them. So cytochrome 1 is NAD.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Cytochrome 2 is riboflavin, vitamin B2, and succinic acid. Cytochrome 3 is CoQ10, vitamin K2. Cytochrome 4 is methylene blue, which we can talk about. And then cytochrome 5 are things like magnesium, vitamin A, and copper. So if you're thinking about mitochondrial health, if you include any or better all of those, you're going to maximize how your mitochondria can work and make energy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Cytochrome 2 is riboflavin, vitamin B2, and succinic acid. Cytochrome 3 is CoQ10, vitamin K2. Cytochrome 4 is methylene blue, which we can talk about. And then cytochrome 5 are things like magnesium, vitamin A, and copper. So if you're thinking about mitochondrial health, if you include any or better all of those, you're going to maximize how your mitochondria can work and make energy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

Cytochrome 2 is riboflavin, vitamin B2, and succinic acid. Cytochrome 3 is CoQ10, vitamin K2. Cytochrome 4 is methylene blue, which we can talk about. And then cytochrome 5 are things like magnesium, vitamin A, and copper. So if you're thinking about mitochondrial health, if you include any or better all of those, you're going to maximize how your mitochondria can work and make energy.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

It's the strongest way to do it. And it's, again, not necessarily complicated. So when I think of CoQ10, and again, we use a lot of NAD, which we can talk about, where I think most people, the traffic congestion happens on cytochrome one, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

It's the strongest way to do it. And it's, again, not necessarily complicated. So when I think of CoQ10, and again, we use a lot of NAD, which we can talk about, where I think most people, the traffic congestion happens on cytochrome one, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

It's the strongest way to do it. And it's, again, not necessarily complicated. So when I think of CoQ10, and again, we use a lot of NAD, which we can talk about, where I think most people, the traffic congestion happens on cytochrome one, right?

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so when we give people or upregulate their NAD production, it's essentially we're allowing for more electron flow at cytochrome one, which has a downstream effect on the other cytochromes, so the traffic jam opens up. And now you can move electrons to exchange for protons and make way more ATP. But that's not true for everyone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so when we give people or upregulate their NAD production, it's essentially we're allowing for more electron flow at cytochrome one, which has a downstream effect on the other cytochromes, so the traffic jam opens up. And now you can move electrons to exchange for protons and make way more ATP. But that's not true for everyone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so when we give people or upregulate their NAD production, it's essentially we're allowing for more electron flow at cytochrome one, which has a downstream effect on the other cytochromes, so the traffic jam opens up. And now you can move electrons to exchange for protons and make way more ATP. But that's not true for everyone.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so some people, it could be at cytochrome three with CoQ10, it could be at cytochrome two, A lot of people have cytochrome 4, which is, again, cytochrome, we call it cytochrome C oxidase, which is where methylene blue binds. But that's just a simplistic view. We just, people, we run into traffic jams, right? These electron flow gets stuck. We're just trying to open up the traffic jam.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so some people, it could be at cytochrome three with CoQ10, it could be at cytochrome two, A lot of people have cytochrome 4, which is, again, cytochrome, we call it cytochrome C oxidase, which is where methylene blue binds. But that's just a simplistic view. We just, people, we run into traffic jams, right? These electron flow gets stuck. We're just trying to open up the traffic jam.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

And so some people, it could be at cytochrome three with CoQ10, it could be at cytochrome two, A lot of people have cytochrome 4, which is, again, cytochrome, we call it cytochrome C oxidase, which is where methylene blue binds. But that's just a simplistic view. We just, people, we run into traffic jams, right? These electron flow gets stuck. We're just trying to open up the traffic jam.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

For sure. And CoQ10 has been studied very safe, up to 2,400 milligrams a day, no harmful effects. Sometimes I'll take more, like I was telling you earlier, it's been dramatic for me with migraine headaches and basically reducing them to zero.

Huberman Lab
Peptide & Hormone Therapies for Health, Performance & Longevity | Dr. Craig Koniver

For sure. And CoQ10 has been studied very safe, up to 2,400 milligrams a day, no harmful effects. Sometimes I'll take more, like I was telling you earlier, it's been dramatic for me with migraine headaches and basically reducing them to zero.