Dr. Dale Bredesen

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108 appearances 2 recordings 2 series first heard Apr 2025 last heard May 2025

Dr. Dale Bredesen’s voice in public audio — every appearance, attributed to the second.

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Dhru Purohit Show · How to Make It To 100 With A Sharp Brain And Good Mobility · 19 May 2025 podcast
So it turned out, and she kind of put it off for several months, and it turned out she had Babesia, so a tick-borne illness. And so that was treated and she now improved once again.
Absolutely. And then she found out that she actually had a large mycotoxin exposure. And it was interesting, you know, when I finally convinced her to get a TGF beta one, because that kind of tells you, are you fighting this ongoing inflammation? And you shouldn't have, it shouldn't be more than 2,380. Hers was 40,000.
So she had massive, massive ongoing inflammation and it turned out to be due to both Babesia and to mycotoxins. And she's done a great job and she's doing well to this day. So unfortunately, yes, you've got to search. This is, you know, you've got to do a little Sherlock Holmes work here to figure out what's actually driving this decline. But the good news is exactly what you said.
Everyone can do the basics. The basics. And everyone can get a response to those basics. But then you're going to want to sustain that response. You're going to want to then continue to target the things that are actually driving the problem.
So let's talk about those seven basics, if you could walk us through. It's a great point. And you know, the only way for us to be efficient, because you can't do a million-dollar workup on every person. So my argument is, look, everyone do the basics, and then most people will never have a problem. A few people will fall through the cracks. Okay, now they need more evaluation.
So let's start with the basics, as you said. And those are, start with diet, a plant-rich, mildly ketogenic diet with appropriate periods of fasting.
And by the way, the most common thing I've heard is people say to me, well, you're telling me I gotta go figure out where to buy organic stuff, I gotta figure out what kind of grass-fed beef to get, where to get wild-caught fish, how to prepare all this stuff. This is now getting simpler and simpler, and I give great credit
to Nutrition for Longevity, of course, founded by Walter Longo and his partner, Jennifer Maynard. They did a fantastic job. So they have now, starting today literally, put together the KetoFlex 12-3 diet. And this is a diet which is just based on synaptogenesis. How are you going to make and keep your synapses? And yes, it's heart healthy as well.
By the way, it's also anti-diabetic because it's going to improve your insulin sensitivity. So you can now order meals. I've had them. They're actually delicious. I was impressed with the job that they did. And you mentioned before we started that you've actually been out to their farms.
Yeah.
I couldn't agree more. And actually, you know, Walter is one of my colleagues all the way back from UCLA when we were both starting out. He was actually a graduate student and I was a young assistant professor. And actually, he and I published some papers together with his mentor there, Dr. Joan Valentine. So I really enjoyed Walter from his first day. And it was interesting to me.
He was the grad student of all the ones I met over the years who knew from day one what he wanted to do, what experiments he wanted to do. Very impressive graduate student. So it's just great to see all the great work that Walter's doing. And I give great kudos to Nutrition for Longevity for coming out with KetoFlex 12-3. And as you mentioned, it's a different strategy.
So I remember actually when I was on the NIA council, Walter came and presented to us at the NIH and presented his idea. This was many years ago, presented his idea for what became this longevity associated diet. And initially they were using it for cancer related things. And of course it has a nice anti-neoplastic effect.
And this is something that you do intermittently, whereas KetoFlex 12-3 is something that helps your brain every day. So it's a different strategy. And you can do both because you can do the intermittent work, for example, with a fasting-mimicking diet or with a longevity-related diet, as well as doing this mildly ketogenic plant-rich. And yes, it absolutely has protein.
There's a pescatarian option we have and a flexitarian option. So it does have grass-fed beef and it does have chicken and all that sort of stuff.
It's fantastic. Yeah. So it's got all these things and we agree that you want to avoid sarcopenia at all costs.
I'm actually in the middle of reading his book right now. So Brain Energy. Yes. Very interesting work. And he makes a compelling case. And I know he's got data. I'm looking for... that first big series to say, okay, we did this in X number of people and what percentage actually got better. But I agree with you. And actually, Rob Lustig was the one who told me what a wonderful book that was.
And so I got it and I'm reading it right now.
Absolutely. It's interesting to me. He looked at mental illness. We looked at neurodegenerative illness. We came to the same conclusions, that there's a mismatch. Not enough supply, too much demand. In my case, we're looking at demand for synaptogenesis. In his case, he's looking at demand for good mental health, basically. But, you know, you look at, for example, the studies in schizophrenia.
There is a reduction in the number of synapses. There is a change in the structure of the neurons. So there are things just beyond, you know, DSM. I guess they're up to DSM-5 now, just looking at symptoms. There are functional and structural changes in And so energetics seem to play a large role in both the neurodegenerative side and on the mental health side, as he points out in his book.
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