Dr. Darren Candow

Use for cancer, yeah, and treatment sepsis and things like that.

Yeah.

It's interesting because I was the first to do glutamine at a very high dose in weight training based on the premise that if it did have any catabolic effects for cancer, long duration, and that was my master's thesis, and we didn't see any effect.

Probably going back to our initial start where resistance might not be stressful or catabolic enough in

continuous duration compared to long duration events.

So that's very interesting.

Yeah, no, I'm very familiar.

I had to do the whole literature search, and it was a higher dose, and they also looked at it for sepsis, but the immune system response, T4 and T8, I don't think were nearly as high.

And that was from long duration.

And a young, healthy individual, they probably might not notice any effect.

But again, that was the idea, the premise behind it was more of an anti-catabolic response.

And why it didn't work for me, it was a non-essential amino acid.

And of course, for protein synthesis, you need all the essentials.

So it was a trying moment when I was doing my master's, but it works out in understanding it.

They do right next to the astrocytes, which don't.

So the endothelial cells at the blood brain barrier, especially, but around all the smooth muscle, they do have the transporter.

So that was one of the theories Mike Ormsby just put out a study in Eric Ross and just recently in older adults.

And that makes sense because you look at a population that might get some benefits and they show some very small favorable effects from creatine supplementation, either a week long or for up to four weeks, I believe.

It was a loading phase and then down to about five grams a day.

So it has some favorable effects for endothelial, I think, with macro and microvascular function.