Dr. Darren Candow

And there's another thing called neurofilament or light chain.

It's an indication of neuronal damage.

And one gram of creatine in your diet has been shown to reduce that.

So there's potential there.

But the overarching thing with antidepressant is it increases brain bioenergetics, as you mentioned, and decreases, again, here we go, mitochondrial health, decreases reactive oxidative species.

All these are implicated in all the

brain and cognitive decline and primarily depression.

So I'm really excited in that area.

A big RCT needs to be done, though, because it's always being added to either cognitive behavior therapy or SSRIs, yeah, for sure.

Yeah, and 100%.

So the anti-inflammatory role comes back there as well.

So you'll start to hear these two words, anti-catabolic and anti-inflammatory.

People think of Advil or Tylenol from an anti-inflammatory, but creatine seems to work very similar in the COX inhibitors as well, but it seems to decrease cytokines.

So it could be something there to consider, yeah.

Yeah, there's been some cellular data around the immune system cells, around creatine, specifically around T cells or macrophages.

That's where the anti-cancer idea came in from creatine, specifically like regarding lymphoma, leukemia.

So that's more in vitro.

There's a lot of work needs to be done.

But there's a lot of studies now looking at the anti-cancer potential of creatines, primarily from the anti or the heightened immune system response.

Everything, okay, yeah.