Dr. Darren Candow

There's been a few small-scale studies that show benefits, but when you look at a properly sample-sized study, it was a big one five years in Germany, didn't see any greater effects.

So again, maybe the dose was too... When I look at the dose, they used it, but very small compared to now our body of evidence suggesting higher dose, big sample size.

And then, of course,

What about the effects of the disease?

Can creatine really rescue the effects to give a significant effect?

We don't know.

Preventing would be the number one thing, but we're starting to do a study in Northern Iowa to look at the effects of creatine now in individuals with cognitive decline.

And I believe there's a study out of Kansas that are actually looking at people with diagnosed Alzheimer's.

So super excited to see these results, if it can have any effect, even help one person, even regardless of a statistical effect, if it can have individual results.

I think it's something we need to consider.

Yes, there has.

It's an emerging area, primarily Utah.

There's a great psychiatry group there.

And as a caveat, no study has ever looked at creatine without antidepressant medications.

So they're always as adjuncts.

So we're not saying creatine could ever replace anxiety or antidepressant medications.

But in these subpopulations, primarily females with clinical depression, it's really starting to have some speed up recovery and decrease some of the symptoms.

The mechanisms are starting to emerge now.

It's starting to have a role primarily from rodents, and this is implicated in depression where they have reduced brain creatine stores, so maybe creatine supplementation can bring those levels up.

There's potential to increase BDNF, so that has been implicated there as well.