Dr. Darren Candow

Now I say take it every day and hope some is going to go to your brain and muscle, or sorry, bone, because on the days you're not working out, your muscle is not sucking it in as fast.

Maybe those other tissues are getting replenished.

Yeah, I would take it any in close proximity to exercise.

I would take it.

So if you work out twice a day, you're taking creatine twice a day.

But if you take it in the morning and then work out later in the night, that's totally fine.

We're not seeing any big differences.

But I'm a big advantageous proponent of taking in close proximity to exercise.

And that's within an hour pre and post.

Yes, I'm one of the rare people, and most people argue against me, I don't do it either.

So there's two ways to look at this.

The pharmacokinetics of creatine and caffeine do not oppose each other.

But from a cellular perspective, they certainly do.

So remember when I talked about the sarcoplasm reticulum, caffeine likes to release calcium, but creatine likes to take it in.

And some really good research out of Europe have shown that the two molecules oppose each other from a muscle relaxation time.

But the dose of caffeine seems to be the most important factor.

If the dose is over 250 milligrams or even higher, that's when it seems to have the interference effect.

If the dose is lower, it doesn't seem to have an interference effect.

So the average large black coffee from Starbucks might be 300, 400 milligrams of caffeine.

So if you were to put your scoop of creatine in there and sip on it for hours...