Dr. Dave Rabin

When we are now in a phase of food surplus, so the same people that inherited these gene changes around slowing metabolism in times of famine are now

Have endless food anytime you want, healthy or unhealthy.

It's all available all the time.

The same genes or gene changes are still existing in those people that are decreasing metabolic speed and rate.

So they are more likely to develop obesity, metabolic disorder, type 2 diabetes, all of those kinds of issues.

because their metabolic system is not prepared for food surplus.

It's prepared for famine, right?

So they're storing, they're in a conservation state where they're not burning off as much of the food because

they're the first generation to experience food surplus right from coming from famine.

So that is a way that trauma gets passed down over time.

That actually exists with mental and emotional trauma as well.

Interesting.

And that was discovered about 20 or 30 years ago.

in some really groundbreaking work by Dr. Rachel Yehuda.

I also go into great detail about this in the book because I think it's one of the most interesting discoveries of the last 20, 30 years in neuroscience.

And that what's really exciting is that we now know we can actually fix it.

So thanks to psychedelic-assisted therapy, we've been working with people with severe PTSD, with MAPS and other researchers, and we published a paper in 2017.

This is 2021 in Frontiers in Psychiatry, which is the first study looking at the epigenetic shifts on cortisol receptors.

So one of the major stress response genes before and after MDMA assisted therapy in people with severe PTSD who are known to have trauma induced changes to their cortisol receptor gene.

And when we looked at those people, we were able to see that when people go through just three doses of MDMA assisted therapy,