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Dr. David Fajgenbaum

๐Ÿ‘ค Speaker
1737 total appearances

Appearances Over Time

Podcast Appearances

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And that's when I told them that I'm going to dedicate the rest of my life, however long that is, trying to find a treatment for Castleman disease.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And I didn't know what that would be.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And frankly, I didn't have a billion dollars in 10 years to create a new drug, which is about how much time and money it costs if you want to make a brand new drug.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So I didn't have the money and I didn't have the time, but I had a really simple and important realization, and that was those seven chemotherapies that I kept getting that kept sort of barely saving my life, none of them were made for Castleman disease.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

They were all made for cancer of the lymph nodes for lymphoma.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

but they were saving my life from Castleman.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So I was like, well, wait a minute.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

You're telling me there's no more drugs for Castleman disease, but you just used seven drugs for lymphoma and those just saved my life.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So like, what if there's an eighth drug for lymphoma?

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

What if there's a ninth drug for something else that could work for Castleman's?

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And my doctors were sort of like, well, but there's nothing else that we know of.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And I'm like, yeah, but have we tried all 4,000 drugs for Castleman disease?

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And so that became my just total like locked in focus.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

It was like, I can't develop a new drug from scratch.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I want to get married to Caitlin, have a family.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I want to develop drugs and treat patients.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

I got to find a drug that already exists for something else.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And then I got to try it on me.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And that became just my total focus.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Where do you start?