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Dr. David Fajgenbaum

๐Ÿ‘ค Speaker
1737 total appearances

Appearances Over Time

Podcast Appearances

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

We train the algorithm over and over again on all the known treatments, and it gets really good at picking up the pattern of connections.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Okay, if that drug treats that disease and that drug treats that disease, and then we say, okay, now that you know what a good treatment looks like in this map of knowledge, now give me a score from zero to one for how likely every other drug is to treat every other disease.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

There's 4,000 drugs, there's 18,000 diseases.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

We're basically asking it to calculate 75 million times, the 4,000 drugs against 18,000 diseases, 75 million times how likely every drug is to treat every disease.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And it's between zero and one.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So then our medical team, we look at the things at the very top and say, what are the 0.99s?

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

What's machine learning, artificial intelligence saying is the highest, most likely drug to treat a disease?

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And that's where we start.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Wow.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

So it sifts through everything.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

It sifts through everything.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

It goes through the world's knowledge.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And actually, when we ran it for the first time, Sean, we built the nonprofit three years ago, spent a lot of our first year fundraising.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

But we finally hired our first data scientist.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

We finally ran the algorithm for the first time about two and a half years ago.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And it took 100 days to run the algorithm.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

to like literally scan everything the world knows about everything, 100 days.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

And we didn't know it would take 100 days, but like just every day it's like slow and we don't have the results back.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Finally, the results 100 days.

The Shawn Ryan Show
#240 Dr. David Fajgenbaum - Can AI Find Cures to Rare Diseases Using Existing Medicine?

Sean, now it takes 17 hours to scan the world's knowledge of everything to get a score, 75 million scores in 17 hours, which the reason that's really important is because then you can actually improve the algorithm and say, that's actually not the way to do it.