Dr. David Perlmutter

I'd say that first as a counter to the notion of what are the big legs that support this decline would be genetics. Genetics is not that relevant. In fact, playing only about a 5% role that people say, well, I carry the APOE4 allele, therefore I'm at greater risk. But understand that that so-called Alzheimer's gene plays upon other variables that we can absolutely control.

I'd say that first as a counter to the notion of what are the big legs that support this decline would be genetics. Genetics is not that relevant. In fact, playing only about a 5% role that people say, well, I carry the APOE4 allele, therefore I'm at greater risk. But understand that that so-called Alzheimer's gene plays upon other variables that we can absolutely control.

I'd say that first as a counter to the notion of what are the big legs that support this decline would be genetics. Genetics is not that relevant. In fact, playing only about a 5% role that people say, well, I carry the APOE4 allele, therefore I'm at greater risk. But understand that that so-called Alzheimer's gene plays upon other variables that we can absolutely control.

So, you know, the point I want to make for your viewers is really quite simple. And that is if mom or dad had Alzheimer's, or if you know that you, by virtue of your 23andMe or other genetic profile, carry one or two of what are called the APOE4 alleles, which are indeed associated with increased risk for Alzheimer's, All well and good and interesting.

So, you know, the point I want to make for your viewers is really quite simple. And that is if mom or dad had Alzheimer's, or if you know that you, by virtue of your 23andMe or other genetic profile, carry one or two of what are called the APOE4 alleles, which are indeed associated with increased risk for Alzheimer's, All well and good and interesting.

So, you know, the point I want to make for your viewers is really quite simple. And that is if mom or dad had Alzheimer's, or if you know that you, by virtue of your 23andMe or other genetic profile, carry one or two of what are called the APOE4 alleles, which are indeed associated with increased risk for Alzheimer's, All well and good and interesting.

No question that having that genetic predisposition and others, presenilin-1, for example, increase your risk. But by all means, the dye isn't cast. It means that our choices, we have control over things that are really influential. And

No question that having that genetic predisposition and others, presenilin-1, for example, increase your risk. But by all means, the dye isn't cast. It means that our choices, we have control over things that are really influential. And

No question that having that genetic predisposition and others, presenilin-1, for example, increase your risk. But by all means, the dye isn't cast. It means that our choices, we have control over things that are really influential. And

I think the biggest issue would be, and they're all important, don't get me wrong, but I think the biggest issue, at least in our modern world, has to do with our metabolism and elevation of our blood sugar, and therefore compromise of our ability to have insulin in the body do its job. And I think... To take a step back, back to high school biology, well, what's the importance of insulin?

I think the biggest issue would be, and they're all important, don't get me wrong, but I think the biggest issue, at least in our modern world, has to do with our metabolism and elevation of our blood sugar, and therefore compromise of our ability to have insulin in the body do its job. And I think... To take a step back, back to high school biology, well, what's the importance of insulin?

I think the biggest issue would be, and they're all important, don't get me wrong, but I think the biggest issue, at least in our modern world, has to do with our metabolism and elevation of our blood sugar, and therefore compromise of our ability to have insulin in the body do its job. And I think... To take a step back, back to high school biology, well, what's the importance of insulin?

Insulin is important for getting glucose or sugar into the cell and therefore lowering or regulating blood sugar levels. Well, all well and good, but I think that we have a tendency to be really myopic when we assign our understanding of insulin or glucose other things in the body, other metrics to a specific, uh, area to the exclusion of other functionality.

Insulin is important for getting glucose or sugar into the cell and therefore lowering or regulating blood sugar levels. Well, all well and good, but I think that we have a tendency to be really myopic when we assign our understanding of insulin or glucose other things in the body, other metrics to a specific, uh, area to the exclusion of other functionality.

Insulin is important for getting glucose or sugar into the cell and therefore lowering or regulating blood sugar levels. Well, all well and good, but I think that we have a tendency to be really myopic when we assign our understanding of insulin or glucose other things in the body, other metrics to a specific, uh, area to the exclusion of other functionality.

And, you know, for example, we say, well, testosterone is the male hormone. You know, women need testosterone, very important. Uh, progesterone was named because it's pro gestation. It's the, you know, a female hormone that goes up during a gestation. Why would my body have progesterone receptors? I think it's important to expand less in this case, uh,

And, you know, for example, we say, well, testosterone is the male hormone. You know, women need testosterone, very important. Uh, progesterone was named because it's pro gestation. It's the, you know, a female hormone that goes up during a gestation. Why would my body have progesterone receptors? I think it's important to expand less in this case, uh,

And, you know, for example, we say, well, testosterone is the male hormone. You know, women need testosterone, very important. Uh, progesterone was named because it's pro gestation. It's the, you know, a female hormone that goes up during a gestation. Why would my body have progesterone receptors? I think it's important to expand less in this case, uh,

on what insulin does in the human body, and specifically vis-a-vis our conversation now, how does insulin relate to the brain? Well, insulin does play a role in allowing brain energetics. We'll come back to that in a moment, but it's the way that blood sugar gets into the brain glucose to ultimately lead to the powering of the brain cells, the neurons specifically.

on what insulin does in the human body, and specifically vis-a-vis our conversation now, how does insulin relate to the brain? Well, insulin does play a role in allowing brain energetics. We'll come back to that in a moment, but it's the way that blood sugar gets into the brain glucose to ultimately lead to the powering of the brain cells, the neurons specifically.