Dr. David Perlmutter

on what insulin does in the human body, and specifically vis-a-vis our conversation now, how does insulin relate to the brain? Well, insulin does play a role in allowing brain energetics. We'll come back to that in a moment, but it's the way that blood sugar gets into the brain glucose to ultimately lead to the powering of the brain cells, the neurons specifically.

And that's really important when our Bodies become insulin resistant. We'll talk about how we get there. I guess I'm paving the way for a lot of conversation. Then that functionality, brain energetics is compromised. That's a bad thing. We can scan brains 20 years ahead of time

And that's really important when our Bodies become insulin resistant. We'll talk about how we get there. I guess I'm paving the way for a lot of conversation. Then that functionality, brain energetics is compromised. That's a bad thing. We can scan brains 20 years ahead of time

And that's really important when our Bodies become insulin resistant. We'll talk about how we get there. I guess I'm paving the way for a lot of conversation. Then that functionality, brain energetics is compromised. That's a bad thing. We can scan brains 20 years ahead of time

and determine already when there is compromised brain energetics that is the harbinger for future cognitive decline and ultimately Alzheimer's disease. And that means, tangentially, that the choices we make in our 30s, 40s, and 50s are very relevant because they, again, portend cognitive decline and full-blown Alzheimer's disease.

and determine already when there is compromised brain energetics that is the harbinger for future cognitive decline and ultimately Alzheimer's disease. And that means, tangentially, that the choices we make in our 30s, 40s, and 50s are very relevant because they, again, portend cognitive decline and full-blown Alzheimer's disease.

and determine already when there is compromised brain energetics that is the harbinger for future cognitive decline and ultimately Alzheimer's disease. And that means, tangentially, that the choices we make in our 30s, 40s, and 50s are very relevant because they, again, portend cognitive decline and full-blown Alzheimer's disease.

Other things, however, that insulin does I think are very important. For example, We know that insulin is degraded in the brain. by something called, oddly enough, insulin degrading enzyme.

Other things, however, that insulin does I think are very important. For example, We know that insulin is degraded in the brain. by something called, oddly enough, insulin degrading enzyme.

Other things, however, that insulin does I think are very important. For example, We know that insulin is degraded in the brain. by something called, oddly enough, insulin degrading enzyme.

Well, it turns out that when we're unable to stimulate adequately this insulin degrading enzyme because insulin functionality is compromised, that that same enzyme is involved in the degradation of this protein we referred to earlier called beta amyloid. So that's now a connection between insulin and beta amyloid. We know that insulin is important for, again, regulating blood sugar.

Well, it turns out that when we're unable to stimulate adequately this insulin degrading enzyme because insulin functionality is compromised, that that same enzyme is involved in the degradation of this protein we referred to earlier called beta amyloid. So that's now a connection between insulin and beta amyloid. We know that insulin is important for, again, regulating blood sugar.

Well, it turns out that when we're unable to stimulate adequately this insulin degrading enzyme because insulin functionality is compromised, that that same enzyme is involved in the degradation of this protein we referred to earlier called beta amyloid. So that's now a connection between insulin and beta amyloid. We know that insulin is important for, again, regulating blood sugar.

And why is that important? Because when our blood sugar is elevated, we change our proteins via something called this process of glycosylation, where proteins bind And that's an issue because not only does it change what the proteins look like in terms of their three dimensionality, but it also, because of those changes, alerts the immune system that, hey, here's a protein I've never seen before.

And why is that important? Because when our blood sugar is elevated, we change our proteins via something called this process of glycosylation, where proteins bind And that's an issue because not only does it change what the proteins look like in terms of their three dimensionality, but it also, because of those changes, alerts the immune system that, hey, here's a protein I've never seen before.

And why is that important? Because when our blood sugar is elevated, we change our proteins via something called this process of glycosylation, where proteins bind And that's an issue because not only does it change what the proteins look like in terms of their three dimensionality, but it also, because of those changes, alerts the immune system that, hey, here's a protein I've never seen before.

And what happens? The immune system gets activated and inflammation gets turned on. And inflammation is really a central player in what degrades the brain in Alzheimer's. So

And what happens? The immune system gets activated and inflammation gets turned on. And inflammation is really a central player in what degrades the brain in Alzheimer's. So

And what happens? The immune system gets activated and inflammation gets turned on. And inflammation is really a central player in what degrades the brain in Alzheimer's. So

The point I'm making then is regulation, balancing our blood sugar, keeping our blood sugar under control is, while everything is important, I think that might well be perhaps the most important issue in terms of what throws the widest net, in terms of for your viewers, what they need to pay attention to, that this blood sugar regulation is in the front row.