Dr. David Sinclair

So the sirtuins will mainly respond to sugar and insulin.

And then there's this other system called mTOR, which is sensing how much protein or amino acids are coming into your body.

And they talk to each other.

We can pull one and affect the other and vice versa.

But together, when you're fasting,

you'll get the sirtuin activation, which is good for you.

And you'll also, through lack of amino acids, particularly three of them, leucine, isoleucine, valine, the body will downregulate mTOR.

And it's that up sirtuin, down mTOR that is hugely beneficial and turns on all of the body's defenses.

Chewing up the old proteins, improving insulin sensitivity, giving us more energy, repairing cells.

all of that.

And so these two pathways, I think, are the most important for longevity.

You mentioned leucine.

Is that right?

That's what the evidence suggests.

And again, it goes back to the debate, should you supplement with growth hormone or testosterone?

All of these activities will give you immediate benefits.

You'll bulk up more.

You'll feel better immediately.

But based on the research, it's at the expense of long-term health.

So my view of longevity, the way I treat my body is I don't burn both candles.