Dr. David Sinclair

There's a lot of physical parts to it.

But try to make it through the first three weeks and do without breakfast or do without dinner.

And you'll get through it.

Not very often.

I find it quite difficult to go more than 24 hours.

But when I do it, maybe it's once a month, I'll go for two days.

After two, and actually even better if you go for three days without eating, it kicks in even greater longevity benefits.

So there's a system called the autophagy system, which digests old and misfolded proteins in the body.

And there's a natural cleansing that happens when you're hungry.

macro autophagy its name is, but a good friend of mine, Anna Maria Cuervo at Albert Einstein College of Medicine discovered a deep cleanse called the chaperone mediated autophagy, which kicks in day two, day three, which really gets rid of the deep proteins.

And what excites me is she just put out a big paper that said, if you trigger this process in an old mouse, it lives 35% longer.

Well, it makes sense, but I haven't had a need to do it, so I don't.

I drink tea during the day and coffee when I'm first awake, and I don't get the shakes.

I don't fix what's not broken.

That proves you're a scientist, or the world leading one.

So what we now know is that these longevity pathways, we call them, these longevity genes talk to each other.

And we used to say, oh, my longevity gene's more important than yours.

It was ridiculous.

because they're all talking to each other, you pull one lever and the other one moves.

And the way to think of it is that there are systems set up to detect what you're eating.