Dr. David Sinclair

And we showed in 2005 in a science paper that

If you have low levels of insulin and another molecule called insulin-like growth factor, those low levels turn on the longevity genes.

One of them that's really important is called SIRT1.

But by having high levels of insulin all day, being fed means your longevity genes are not switched on.

So you're falling apart.

Your epigenome, your information that keeps your cells functioning over time just degrades quicker.

Your clock is ticking faster by always being fed.

The other thing that I think might be happening by always having food around is that it's not allowing the cell to have periods of rest and reestablish the epigenome.

And so it also is accelerating in that direction.

There's plenty of other reasons as well that are not as profound, such as having low levels of glucose in your body will trigger your major muscles in your brain to become more sensitive to insulin and suck the glucose out of your bloodstream, which is very good.

You don't want to have glucose flowing around too much.

And that will ward off type 2 diabetes.

What is the protocol that people can extrapolate from that?

Well, if there's one thing I could say, I would say definitely try to skip a meal a day.

That's the best thing.

Does it matter which meal?

Or the essential equivalent?

Well, as long as it's at the end or the beginning of the day, because then you add that to the sleep period where you're hopefully not eating.

Beware that the first two to three weeks when you try that, you will feel hungry.

And you also have a habit of wanting to chew on something.