Dr. David Sinclair

A lot of people don't know that.

You can touch your brain if you touch your eye.

So the optic nerve gets old.

And what we've discovered, if it gets damaged or gets old, it's not working.

But the nerves, for the most part, if you're old, are still there.

They just forget how to work.

And that's aging.

And later, everyone should stick around because I'm going to tell you

why it is we get old and how it is we reverse it.

But for this model, what we're doing is we're introducing a set of three genes into this optic nerve at the back of the eye and turning them on for six to eight weeks.

And those three genes are what we now know reset safely, apparently safely, reset the age of cells, including nerves, by about 75% and then stop.

They don't go more than that, which is good.

We don't want to go back to zero.

I don't think anyone wants to go back to high school.

But this is the way it works.

And we chose the optic nerve because it's a safe and closed system, not because it should work better in optic nerves.

In fact, we've now done it in mice in my lab for the brain.

We're doing hearing.

We've done skin.

We did multiple sclerosis.