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Dr. David Sinclair

๐Ÿ‘ค Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

and every day spends my life researching with a team of the best scientists I can gather around the world, showing that we can literally now reverse the aging process and reset how old the body is.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

In animals, yes, but potentially this year, showing it can work in the human body as well.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Yes.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So we've submitted a form to the

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

You know, the FDA in the US to get approval to treat blindness, a couple of types of blindness in people as early, if all goes well, as next month.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Yeah, well, we chose the eye not because it was going to work well, but because it's a nice system to study age reversal.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

The eye is an enclosed space, and so it's much safer than trying to initially reverse the age of the whole body.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Now, in mice, we reverse the age of the whole body.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And the effect is longevity, rejuvenation, the skin gets better, all parts of the animal get healthier and younger.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

But in humans, you don't want to go straight to rejuvenation, because in case something goes wrong, it could set us way back.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And we have to make sure we don't have any safety mishaps.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So we're being a little cautious in humans.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

In mice, it's a little different.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So in the human eye... Just for those that aren't watching the video, there is an eye on the table.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Well, a plastic eye.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It's a larger version of an eye, but yes, Stephen's right.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

What we're doing, we're going to look at the back of the eye, which is your retina, and that's where the light hits.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And at that point, there are a lot of nerves that coalesce into the optic nerve that runs to the brain by just a few millimetres.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So the brain is here.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

The eye is actually part of the brain.