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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And by exercising, I will maintain that and have.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In fact, I probably haven't had a body like this since I was 20.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So that's one of the benefits of having this lifestyle.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I don't want to get too much into the anecdotes, but I'll tell you the science, which is that

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

If you take a mouse and put it on fasting or caloric restriction up until the point where it should be infertile, so that's about it, at a year of age, a mouse gets infertile, female mouse.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Due to fasting or due to simply to aging?

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Due to aging.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Due to aging.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

The fasting, it's not an extreme fast.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's just less calories.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Got it.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Then you put them back on a regular food and they become fertile again.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

for many, many months afterwards.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So the effect on slowing down aging is also on the reproductive system.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Interesting.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And so I wouldn't say to any woman, I wouldn't think that they should become super skinny to try and preserve fertility.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

That's not what I'm saying.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But these pathways that we work on, these sirtuins, are known to delay infertility in female animals.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Case in point, I'm one of the lead authors on a paper where we used NMN.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Remember, this is the gas, the fuel, the petrol for the sirtuins.