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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It is the best marker for cardiovascular inflammation and also we use it as a predictor of

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

longevity and its levels go up with

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

mortality.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And so this is an association, but there's enough data that I would say if you have high levels of CRP, you need to get your levels down quickly.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And the levels usually go up with age and with levels of inflammation.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So the ways to get it down would be to switch the diet, eat less, try to eat more vegetables.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

You'll find it will come down.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

There are also drugs that can do it.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Anti-inflammatories can do it as well.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But CRP is, it's actually HCRP.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

There's a high sensitive or HSCRP.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Your doctor will know.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Get one of those readings because if you've got normal blood sugar levels, your doctor, or fasting blood sugar levels, your doctor might say you're fine.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But a lot of people have normal blood sugar but have high CRP, which is just as bad for you long-term and can predict a future heart attack.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

What do you do?

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Well, we know that aerobic exercise in mice and rats raises their NAD levels and their levels of SIRT, one of the genes goes up to actually number one and number three.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I base my exercise on the scientific literature, which has shown that

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Maintaining muscle mass is very important for a number of reasons.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

The two main ones are you want to maintain your hormone levels.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I'm an older male, losing my testosterone and muscle mass over time.