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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

This is a new finding out of Spain.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Manuel Serrano's lab has found that

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

excess iron will increase the number of senescent cells in the body.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And senescent cells are these zombie cells that accumulate as you get older and they sit there and they cause inflammation mainly and also can cause cancer.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And it's found that if you get rid of these cells or never accumulate them, you stay younger.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In animals, and there's a

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

some really interesting studies out of Mayo Clinic in humans as well.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And what I find, for example, is people who are really healthy and live the way I do and have a diet that's fairly vegetarian, but not strict, still have slightly low hemoglobin levels, slightly low iron, slightly low ferritin, but we have super amounts of energy.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

We're not anemic.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And we're getting along great in life.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But a doctor who just looks at that might say, oh, we need to give you more iron.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So what I'm getting at is an example of we need to personalize medicine and look at people over the long run to know what works for them and what's healthy for them.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And not just work towards the average human, but work towards what's optimal for human.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Yeah.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

The first is that you should be tracking things because one measurement isn't enough.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

These things vary and over time.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And if you can have a decade or more of data, it's super informative, as you know.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But there are some main ones.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I would say your blood sugar levels, you want to do your HbA1c, which is your average glucose levels over the month.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

There's CRP, which I mentioned for inflammation.