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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

both males and females, which is great.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So what you want to do is naturally boost the activity of these sirtuins.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

They are genes, but they also make proteins.

1671.4 View full episode β†’
Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

That's what genes typically make or encode.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And then those proteins take care of the body in many different ways.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

NAD levels are really important for keeping those sirtuin defenses at a youthful level.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I take a precursor to NAD called NMN, and the body uses that to make the NAD molecule in one step.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And so I know from

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

measuring dozens of human beings, that if you take NMN,

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

for the time period that I do.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I've been taking it for years, but if you take it for about two weeks, you'll double, on average, double your NAD levels in the blood.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So I just want people to be aware that what I do may not perfectly work at all for others.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But I have studied, as I said, dozens of people who take NMN at a gram, sometimes two grams.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And I know by looking at all those people that without any exceptions, that if you do what I do, your NAD levels go up.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

by about twofold or more.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Anecdotally, because I've been taking this for a long time, if I don't take it, I start to feel 50 years old.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's horrible.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

I can't think straight.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It may be placebo, but who knows?

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But what we're doing now are very careful clinical trials.