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Dr. David Sinclair

๐Ÿ‘ค Person
348 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

That would be bad.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And those chemicals, there are many different types of chemicals, but one's called methylation.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Those little methyls will mark which songs get played for the rest of your life.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And there are other marks that change daily.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But in total, what we're saying is that the body controls the genome through the ability to mark the DNA and then compact some parts of it.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

silence those genes, don't read those genes, and open others, keep others open, that should stay open.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And that pattern of genes that are silent and open, silent, open, is what dictates the cell's type, the cell's function.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And then the scratches are the disruption of that.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So genes that were once silent

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And you could say it's a gene that is involved in skin.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's starting to come on in the brain, shouldn't be there, but we see this happen and vice versa.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

The gene might get shut off over time during aging.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Cells over time lose these structures, lose their identity.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

They forget what they're supposed to do and we get diseases.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

We call that aging.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And we can measure that.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In fact, we can measure it in such a way that we can predict when somebody's going to die based on the changes in those chemicals.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Well, it's actually you are as old as you look if you want to generalize.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So let's start with centenarian families.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

These are families that tend to live over 100.