Dr. David Sinclair

I recall.

Yeah.

And then the epigenome is the reader that says, okay, in this cell, we need to play that set of songs.

And in this other cell, we have to play a different set of songs.

But over time, aging is the equivalent of scratching.

the CD and the DVD so that you're not playing the right songs.

And cells, when they don't hear the right songs, they get messed up and they don't function well.

And that is what I'm saying is the main driver of aging.

And these other hallmarks are largely manifestations of that process.

What are the scratches that you're referring to?

So DNA is six foot long.

So if you join your chromosomes together, you get about six foot per cell.

So there's enough to go to the moon and back eight times in your body.

And it has to be wrapped up to exist inside us.

But it's not just wrapped up willy-nilly.

It's not just a bundle of string.

It's wrapped up very carefully in ways that dictates which genes are switched on and off.

And when we're developing in the embryo, the cell marks the DNA with chemicals that says, okay, this gene is for a nerve cell.

You, you cell will stay a nerve cell for the next hundred years, if you're lucky.

Don't turn into a skin cell.