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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Sulforaphane is what it sounds.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It has a sulfur atom in it, and that gives it that rotten egg smell.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

But sulforaphane activates these hormesis pathways.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

There's one called NRF, and that is a stress response pathway.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

protein that sulforaphane activates.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So you actually, by eating preferably relatively steamed, not fried to death Brussels sprouts, you'll get sulforaphane.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

You can also take sulforaphane as a supplement if you don't like Brussels sprouts.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Well, there's a few examples.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

The first time I came across this result as a scientist was resveratrol.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

So resveratrol is found in red wine, among other things, and it's thought to give the health benefits of red wine.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And we fed it to mice, fat mice, skinny mice, old mice, and it worked very well in the fat mice.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It made them thinner.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It made them live longer.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

It

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

cured most of their diseases.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

They lived about, I think it was 15, 20% longer.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Then we gave it to normal mice every day.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

And they lived a little bit longer, but not significantly.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Resveratrol.

The Diary Of A CEO with Steven Bartlett
David Sinclair: Can Aging Be Reversed?After 8 Weeks, Cells Appeared 75% Younger In Tests!

Resveratrol.