Dr. David Sinclair

What we found, to my surprise, was when we gave old mice resveratrol not every day, but every second day, then they lived significantly longer.

So then I thought, well, maybe giving them a foreign substance every day is not good.

Maybe there's some side effect that's counteracting the benefit.

The other thing I want to mention, I said there's a few examples.

Another good one is metformin.

Metformin has been shown to make athletes and bodybuilders and people who go to the gym, weightlifters, do less repetitions.

And as a result, their muscles are about 5% less compared to those that don't take metformin in size.

I don't think it's molecular.

I think it's because you feel a little bit weaker with metformin because it's actually interfering with your body's ability to make energy through mitochondria.

Mitochondria, I think most people have heard of the little power packs living in our cells, originally bacteria that came into our bodies.

The point is that by pulsing metformin, I think that's a better way to do it for longevity.

Yeah, I don't take, if I take metformin or the natural equivalent, which is berberine, if you don't want to take the drug, you can take berberine.

That also activates this AMPK, this other sirtuin-like pathway.

Taking it every other day, I think, is better.

And particularly if you like to work out, don't take the metformin a few hours before you work out.

Take it after or maybe skip it that day.

I think that's a better approach.

Yeah, we don't.

We don't.

Unfortunately, all of these association studies just lead to a need to do placebo-controlled or at least controlled trials in people.