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Dr. David Sinclair

πŸ‘€ Speaker
2074 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

We call that aging.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And we can measure that.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

In fact, we can measure it in such a way that we can predict when somebody's going to die based on the changes in those chemicals.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Well, it's actually you are as old as you look if you want to generalize.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So let's start with centenarian families.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

These are families that tend to live over 100.

430.35 View full episode β†’
Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

When they're 70, they still look 50 or less.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So it is a good indicator.

436.18 View full episode β†’
Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's not perfect because you can, like me, grow up in Australia and accelerate the aging of your skin.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

But in general, how you look.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

No one's ever dyed from gray hair, but overall you can get a sense just from the ability of skin to hold itself up, how thin it is, the number of wrinkles.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Yes.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

Really good question.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So those chemicals we can measure, it's also known as the Horvath clock.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's the biological clock.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

It's separate from your chronological age.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

There are some people that are 10, 20 years younger than other people biologically.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

And it turns out if you measure that clock from birth or even before birth, if you look at animals, there's a massive increase in age based on that clock early in life.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So you're right.

Huberman Lab
Essentials: The Biology of Slowing & Reversing Aging | Dr. David Sinclair

So that's a really important point that you have accelerated aging during the first few years of life, and then it goes linear towards the rest of your life.