Dr. David Sinclair

That's the best thing.

Does it matter which meal?

Or the essential equivalent?

Well, as long as it's at the end or the beginning of the day, because then you add that to the sleep period where you're hopefully not eating.

Beware that the first two to three weeks when you try that, you will feel hungry.

And you also have a habit of wanting to chew on something.

There's a lot of physical parts to it.

But try to make it through the first three weeks and do without breakfast or do without dinner.

And you'll get through it.

Not very often.

I find it quite difficult to go more than 24 hours.

But when I do it, maybe it's once a month, I'll go for two days.

After two, and actually even better if you go for three days without eating, it kicks in even greater longevity benefits.

So there's a system called the autophagy system, which digests old and misfolded proteins in the body.

And there's a natural cleansing that happens when you're hungry.

macro autophagy its name is, but a good friend of mine, Anna Maria Cuervo at Albert Einstein College of Medicine discovered a deep cleanse called the chaperone mediated autophagy, which kicks in day two, day three, which really gets rid of the deep proteins.

And what excites me is she just put out a big paper that said, if you trigger this process in an old mouse, it lives 35% longer.

Well, it makes sense, but I haven't had a need to do it, so I don't.

I drink tea during the day and coffee when I'm first awake, and I don't get the shakes.

I don't fix what's not broken.