Dr. David Sinclair

That proves you're a scientist, or the world leading one.

So what we now know is that these longevity pathways, we call them, these longevity genes talk to each other.

And we used to say, oh, my longevity gene's more important than yours.

It was ridiculous.

because they're all talking to each other, you pull one lever and the other one moves.

And the way to think of it is that there are systems set up to detect what you're eating.

So the sirtuins will mainly respond to sugar and insulin.

And then there's this other system called mTOR, which is sensing how much protein or amino acids are coming into your body.

And they talk to each other.

We can pull one and affect the other and vice versa.

But together, when you're fasting,

you'll get the sirtuin activation, which is good for you.

And you'll also, through lack of amino acids, particularly three of them, leucine, isoleucine, valine, the body will downregulate mTOR.

And it's that up sirtuin, down mTOR that is hugely beneficial and turns on all of the body's defenses.

Chewing up the old proteins, improving insulin sensitivity, giving us more energy, repairing cells.

all of that.

And so these two pathways, I think, are the most important for longevity.

You mentioned leucine.

Is that right?

That's what the evidence suggests.