Dr. Diego Bohórquez

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956 appearances 1 recordings 1 series first heard May 2024 last heard May 2024

Dr. Diego Bohórquez’s voice in public audio — every appearance, attributed to the second.

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Huberman Lab · The Science of Your Gut Sense & the Gut-Brain Axis | Dr. Diego Bohórquez · 27 May 2024 podcast

And then these glucagon-like peptide one will act on specific receptors of the nerve terminals and then will trigger some of the behaviors.

It's also thought that it acts at the level of the brainstem.

And what it will potentiate is the reduction of appetite.

So I say that this is a complimentary question because what is happening in the first few milliseconds is the actual choice and the actual feeling of how you feel about food.

And what is happening in the minutes to hours later is the amount.

how much you can eat, right?

And when you should stop, because after four hours, you're gonna come back and feel again the tickling of the gut, because the gut starts to churn again, and it starts to call for food.

Remember, it has to feed two giant organisms, the host itself, but also the microbes that are inside, right?

So it has to keep

so to speak, that hunger going every four hours or so, right?

So that's why the hormones are more acting on the cyclical, circadian way, but the transmitters are acting in this very fast, responsive way of the precise stimuli in specific regions of the gastrointestinal tract.

They are releasing GLP-1.

They're releasing GLP-1 to shut down, transiently shut down hunger.

And probably there is some interaction between the cells that they are having, you know, the technical term is autocrine or they are having like paracrine between the cells, you know, neuromodulation.

But primarily, let's say they respond to the stimulus and release GLP-1 onto the nerve fiber.

So you just touched on an entire realm of a topic, which is one of my favorite topics, because at some point, as scientists, we travel the world.

And it started to become very obvious to me that wherever I went, we solved this issue of food in a very similar way, whether it's a tortilla or two pieces of bread, which is another way of a tortilla.

you have your carbs.

And then you add a little bit of meat or a mushroom, and now you have your protein.

Or fish or chicken.

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