Dr. Glen Jeffery
๐ค SpeakerAppearances Over Time
Podcast Appearances
Their control of their blood glucose, not surprisingly, becomes unbalanced.
And they start to behave slightly peculiarly in open field situations.
Now, you and I know that when you put a mouse in an open field situation, it's a measure of how confident it feels.
So it runs around the edge at first until it feels happy and then it wanders around the middle and the rest of it.
Mice under LED lighting do not make that transition from working around the edge and coming into the center.
And that is possibly consistent with the notion they have low-level infection, chronic infection.
That's all published.
Now, there's some stunning data coming out of another lab.
It will come out early next year showing that these same mice...
have fatty livers, again, not really desperately surprising.
They've got fatty, but there's a clear systemic effect here because their livers are smaller
Their kidneys are smaller and their hearts are slightly smaller.
With the liver problems, we get a raise in what we'll call liver distress signals, proteins coming around what's called ALT, which tells you your liver is not happy at all.
Interestingly...
Where do you also find vast numbers of mitochondria?
You find them in sperm.
So there is a greater concentration of sperm with abnormal swimming capacity and abnormal morphology in those mice.
And the testicles have abnormal morphologies.
Now, these are animals that are really run towards the end of their life.
Okay, but again, let's put all these things together.