Dr. James Gratwick

And this is excellent facial expression.

I mean, there's absolutely no problem with movement of his face at all.

Furthermore, there's very good dexterity in the leg on the right.

There's a little bit of problems I can see with the dexterity in the right hand, but still able to do up shoelaces, which is certainly at 18 years, I've never seen a patient with CBS be able to have the dexterity to do that.

So I must say from what you showed me of this video, this does not particularly to me look like somebody with corticobasal syndrome.

So what's effectively said here is I don't know what's going on.

That's really what's being said.

No, it's really saying I'm not sure what the cause of these symptoms is.

It is saying the closest thing I could think of would be corticobasal syndrome.

But then the caveat at the end there, but it's clearly affected very mildly, is acknowledging the fact that the time course of the symptoms

how long they've been present, he should be much, much more affected by this point if it were corticobasal syndrome.

So the longest person that survived from diagnosis that I have treated is eight or nine years.

Very much so.

So the patient, towards really from I think their sixth year to their eighth year, they were wheelchair-bound.

They were unable to walk.

They had no meaningful ability to move the lower limbs.

Ethically, I don't think it would ever pass an ethics board.

As we said, if you were attempting to get patients with a severe debilitating progressive neurological condition to try and perform physical feats, which are clearly going to be beyond their capability on an ethical basis, that's not ethical.

They would suffer.

And so you couldn't write a trial on that basis.