Dr. Jeff Bland
๐ค SpeakerAppearances Over Time
Podcast Appearances
foreign invaders the macrophage which is a member of those cell type in the innate immune system has these arms as it's a big floppy job of the hut type cell and it puts its arms around foreign stuff and then it squeezes it and then it releases chemical the klebanoff reaction which as you said are hydrogen peroxide and oxidants that kill it so it's chemical warfare it's like pac-man i think of macrophages like pac-man they just go around but you know gobbling up the bad stuff
foreign invaders the macrophage which is a member of those cell type in the innate immune system has these arms as it's a big floppy job of the hut type cell and it puts its arms around foreign stuff and then it squeezes it and then it releases chemical the klebanoff reaction which as you said are hydrogen peroxide and oxidants that kill it so it's chemical warfare it's like pac-man i think of macrophages like pac-man they just go around but you know gobbling up the bad stuff
But there's not much we supposedly can do about that. It's either going to work for us or not. Now, within the last 10 years, da-da, new discovery. The innate immune system can be taught, and it can learn, and it can be trained to be better.
But there's not much we supposedly can do about that. It's either going to work for us or not. Now, within the last 10 years, da-da, new discovery. The innate immune system can be taught, and it can learn, and it can be trained to be better.
But there's not much we supposedly can do about that. It's either going to work for us or not. Now, within the last 10 years, da-da, new discovery. The innate immune system can be taught, and it can learn, and it can be trained to be better.
Let's say why. Because it turns out, if you ask, where is the innate immune system concentrated? Where is it localized in the body in higher levels? It's in the mucosal surfaces. And the first place that our body sees foreigner is where you find most of your innate immune system, like the gut mucosa, the lung epithelia, in the nasal passages.
Let's say why. Because it turns out, if you ask, where is the innate immune system concentrated? Where is it localized in the body in higher levels? It's in the mucosal surfaces. And the first place that our body sees foreigner is where you find most of your innate immune system, like the gut mucosa, the lung epithelia, in the nasal passages.
Let's say why. Because it turns out, if you ask, where is the innate immune system concentrated? Where is it localized in the body in higher levels? It's in the mucosal surfaces. And the first place that our body sees foreigner is where you find most of your innate immune system, like the gut mucosa, the lung epithelia, in the nasal passages.
And so if your innate immune system is kind of not doing the job, then it slips through the innate immune system, whatever that is, And now it has access to the second line of defense. And you talked about this situation that we saw with regard to COVID-19, where people died in their own fluids because their immune system overreacted.
And so if your innate immune system is kind of not doing the job, then it slips through the innate immune system, whatever that is, And now it has access to the second line of defense. And you talked about this situation that we saw with regard to COVID-19, where people died in their own fluids because their immune system overreacted.
And so if your innate immune system is kind of not doing the job, then it slips through the innate immune system, whatever that is, And now it has access to the second line of defense. And you talked about this situation that we saw with regard to COVID-19, where people died in their own fluids because their immune system overreacted.
And they produced all this stuff trying to, well, that's because the innate immune system never had a chance to kind of do its work the first time. And the second set, the adaptive immune system, now got overwhelmed and it just went wild and went into the cytokine storms, what they called it, which was a consequence of
And they produced all this stuff trying to, well, that's because the innate immune system never had a chance to kind of do its work the first time. And the second set, the adaptive immune system, now got overwhelmed and it just went wild and went into the cytokine storms, what they called it, which was a consequence of
And they produced all this stuff trying to, well, that's because the innate immune system never had a chance to kind of do its work the first time. And the second set, the adaptive immune system, now got overwhelmed and it just went wild and went into the cytokine storms, what they called it, which was a consequence of
yikes, I'm under siege, I just have to throw all the tools against it, and that person actually ends up dying of their own immune system overreacting. The construct that we have an appropriate first line of defense, we teach that immune system, the innate immune system, to be vigilant and resilient.
yikes, I'm under siege, I just have to throw all the tools against it, and that person actually ends up dying of their own immune system overreacting. The construct that we have an appropriate first line of defense, we teach that immune system, the innate immune system, to be vigilant and resilient.
yikes, I'm under siege, I just have to throw all the tools against it, and that person actually ends up dying of their own immune system overreacting. The construct that we have an appropriate first line of defense, we teach that immune system, the innate immune system, to be vigilant and resilient.
It's a different kind of specificity. Because on the surface of your innate immune system, you have what are called toll-like receptors. And those toll-like receptors pick up information of specific types, like gut bacterial lipopolysaccharides, and then respond to that by defending you against that message. And
It's a different kind of specificity. Because on the surface of your innate immune system, you have what are called toll-like receptors. And those toll-like receptors pick up information of specific types, like gut bacterial lipopolysaccharides, and then respond to that by defending you against that message. And
It's a different kind of specificity. Because on the surface of your innate immune system, you have what are called toll-like receptors. And those toll-like receptors pick up information of specific types, like gut bacterial lipopolysaccharides, and then respond to that by defending you against that message. And