Dr. Jocelyn Wittstein

The exercise group was like gaining, whereas the other group was losing, as you would expect.

Yeah.

But over time, those gains trailed off.

And near the end of the study, the exercise group was losing bone density, but at a slower rate.

But my point is, and why I like that study so much, is it shows the effectiveness of exercise for fracture prevention, even as bone density is declining maybe at a slower rate.

But there's more to exercise than just the bone density.

It's like your coordination and your balance.

So I like that trial because I think they did such a good job of following through with the fracture risk.

Yeah, so this is a very interesting question.

I read about this a lot.

And I think the confusion around this question comes from there was a study that looked at markers of bone turnover and associated levels of estrogen.

And they found that if the estradiol level was 60 picograms per ml or higher...

basically there was the greatest reduction in markers of bone turnover.

So basically breaking down bone.

We're remodeling.

We remodel.

Yeah, we're remodeling.

Massive acceleration in perimenopause.

And I read a study recently that showed that there are faster and slower bone losers in perimenopause.

And just looking at basically the people who had the greatest bone loss or acceleration bone loss in perimenopause were the women who had the lowest frequency of ovulation.