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Dr. John Kruse

👤 Person
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

It seems to be that it's not just the impulsivity traits, but some of the inattentive ones too. You know, if you're teachers lecturing about the risks of alcohol or this and this, and you're zoning out the window and looking at the plane flying by, You have less pertinent information on the topics.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

It seems to be that it's not just the impulsivity traits, but some of the inattentive ones too. You know, if you're teachers lecturing about the risks of alcohol or this and this, and you're zoning out the window and looking at the plane flying by, You have less pertinent information on the topics.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You may be less attentive to the negative effects that other kids are seeing among the classmates who are stoners at this age or X, Y, or Z. So it seems that both inattentive sets of ADHD symptoms and the impulsive, thrill-seeking, not weighing the consequences as heavily are all contributing to this heightened risk.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You may be less attentive to the negative effects that other kids are seeing among the classmates who are stoners at this age or X, Y, or Z. So it seems that both inattentive sets of ADHD symptoms and the impulsive, thrill-seeking, not weighing the consequences as heavily are all contributing to this heightened risk.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You may be less attentive to the negative effects that other kids are seeing among the classmates who are stoners at this age or X, Y, or Z. So it seems that both inattentive sets of ADHD symptoms and the impulsive, thrill-seeking, not weighing the consequences as heavily are all contributing to this heightened risk.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So Ritalin is, or generic methylphenidate, and there's dozens now of slow release versions and there's even a patch, a skin patch instead of an oral version. Our definition of what a stimulant is is really squishy and vague. In its broadest sense, it's any drug that has an effect in the body, like the sympathetic nervous system, which is a norepinephrine-driven fight-or-flight arousal system.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So Ritalin is, or generic methylphenidate, and there's dozens now of slow release versions and there's even a patch, a skin patch instead of an oral version. Our definition of what a stimulant is is really squishy and vague. In its broadest sense, it's any drug that has an effect in the body, like the sympathetic nervous system, which is a norepinephrine-driven fight-or-flight arousal system.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So Ritalin is, or generic methylphenidate, and there's dozens now of slow release versions and there's even a patch, a skin patch instead of an oral version. Our definition of what a stimulant is is really squishy and vague. In its broadest sense, it's any drug that has an effect in the body, like the sympathetic nervous system, which is a norepinephrine-driven fight-or-flight arousal system.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So by the loosest criteria, caffeine's a stimulant. Well, butane's a stimulant, even though we classify it as an antidepressant. Some of the decongestants are stimulants. But more often when we're talking ADHD medicines, we're using stimulant more specifically for amphetamine-based products like Adderall and Vyvanse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So by the loosest criteria, caffeine's a stimulant. Well, butane's a stimulant, even though we classify it as an antidepressant. Some of the decongestants are stimulants. But more often when we're talking ADHD medicines, we're using stimulant more specifically for amphetamine-based products like Adderall and Vyvanse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So by the loosest criteria, caffeine's a stimulant. Well, butane's a stimulant, even though we classify it as an antidepressant. Some of the decongestants are stimulants. But more often when we're talking ADHD medicines, we're using stimulant more specifically for amphetamine-based products like Adderall and Vyvanse.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, there's a host now of newer branded extended release forms and methylphenidate. And we lump the two together, probably most ADHD experts agree with, and this is where I'm going to be disagreeing with most of them, I don't consider Ritalin a full stimulant. So the neuropharmacologists differ a little bit, but amphetamine... is a strong dopamine and norepinephrine reuptake blocker.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, there's a host now of newer branded extended release forms and methylphenidate. And we lump the two together, probably most ADHD experts agree with, and this is where I'm going to be disagreeing with most of them, I don't consider Ritalin a full stimulant. So the neuropharmacologists differ a little bit, but amphetamine... is a strong dopamine and norepinephrine reuptake blocker.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, there's a host now of newer branded extended release forms and methylphenidate. And we lump the two together, probably most ADHD experts agree with, and this is where I'm going to be disagreeing with most of them, I don't consider Ritalin a full stimulant. So the neuropharmacologists differ a little bit, but amphetamine... is a strong dopamine and norepinephrine reuptake blocker.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So it prevents what's already been released from being taken back up. So more is available longer. But in addition to that, amphetamine is a pretty potent, let's just say, vesicle manipulator. So it's actually forcing a bigger release from the vesicles when they're synaptically released. So it's not just that the signal lasts longer and is stronger because of that. It's a bigger signal.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So it prevents what's already been released from being taken back up. So more is available longer. But in addition to that, amphetamine is a pretty potent, let's just say, vesicle manipulator. So it's actually forcing a bigger release from the vesicles when they're synaptically released. So it's not just that the signal lasts longer and is stronger because of that. It's a bigger signal.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So it prevents what's already been released from being taken back up. So more is available longer. But in addition to that, amphetamine is a pretty potent, let's just say, vesicle manipulator. So it's actually forcing a bigger release from the vesicles when they're synaptically released. So it's not just that the signal lasts longer and is stronger because of that. It's a bigger signal.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Depending on what study you look at, most of the studies suggest that methylphenidate is actually a pretty weak vesicular manipulator, and some studies don't find any impact there at all. Which means if methylphenidate is basically a norepinephrine and dopamine reuptake inhibitor, That's what Welbutrin is. That's one of the components.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Depending on what study you look at, most of the studies suggest that methylphenidate is actually a pretty weak vesicular manipulator, and some studies don't find any impact there at all. Which means if methylphenidate is basically a norepinephrine and dopamine reuptake inhibitor, That's what Welbutrin is. That's one of the components.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Depending on what study you look at, most of the studies suggest that methylphenidate is actually a pretty weak vesicular manipulator, and some studies don't find any impact there at all. Which means if methylphenidate is basically a norepinephrine and dopamine reuptake inhibitor, That's what Welbutrin is. That's one of the components.