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Dr. John Kruse

👤 Person
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And so why I would further say, if you look at the efficacy data, how well do these work in resolving ADHD symptoms? All the meta-analyses lump Adderall products, amphetamine, and methylphenidate products here and say, you know, they're here because they work better. This is, you know, success in reducing ADHD symptoms.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And so why I would further say, if you look at the efficacy data, how well do these work in resolving ADHD symptoms? All the meta-analyses lump Adderall products, amphetamine, and methylphenidate products here and say, you know, they're here because they work better. This is, you know, success in reducing ADHD symptoms.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And so why I would further say, if you look at the efficacy data, how well do these work in resolving ADHD symptoms? All the meta-analyses lump Adderall products, amphetamine, and methylphenidate products here and say, you know, they're here because they work better. This is, you know, success in reducing ADHD symptoms.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And Alvar, Stratera, Adalmoxetine, Welbutrin, I use Cymbalta a lot, Modafinil, Guanfacine, all these other things are down here as less effective. But if you actually look at any of the plots that I've looked at and separate out, methylphenidate is actually closer to the pack below. It's the amphetamine products are head and shoulders above everything else.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And Alvar, Stratera, Adalmoxetine, Welbutrin, I use Cymbalta a lot, Modafinil, Guanfacine, all these other things are down here as less effective. But if you actually look at any of the plots that I've looked at and separate out, methylphenidate is actually closer to the pack below. It's the amphetamine products are head and shoulders above everything else.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And Alvar, Stratera, Adalmoxetine, Welbutrin, I use Cymbalta a lot, Modafinil, Guanfacine, all these other things are down here as less effective. But if you actually look at any of the plots that I've looked at and separate out, methylphenidate is actually closer to the pack below. It's the amphetamine products are head and shoulders above everything else.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Methylphenidate is usually at the top of the rest of the crowd. But if you're just looking at the data objectively, there's a clear decision point. So in terms of efficacy, Amphetamine products are stronger. But in terms of some of the side effect that I worry most about, it's not at all common, but it's one of the horrible ones is amphetamine-induced psychosis.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Methylphenidate is usually at the top of the rest of the crowd. But if you're just looking at the data objectively, there's a clear decision point. So in terms of efficacy, Amphetamine products are stronger. But in terms of some of the side effect that I worry most about, it's not at all common, but it's one of the horrible ones is amphetamine-induced psychosis.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Methylphenidate is usually at the top of the rest of the crowd. But if you're just looking at the data objectively, there's a clear decision point. So in terms of efficacy, Amphetamine products are stronger. But in terms of some of the side effect that I worry most about, it's not at all common, but it's one of the horrible ones is amphetamine-induced psychosis.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Now that we're finally looking at that a little more closely, because for years the ADHD experts have said, yeah, it's really rare, let's not look at it at all, let's not pay attention, move along, you know, don't look. With amphetamine, Adderall products, and that's probably dose dependent, but it's close to one out of 500 people.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Now that we're finally looking at that a little more closely, because for years the ADHD experts have said, yeah, it's really rare, let's not look at it at all, let's not pay attention, move along, you know, don't look. With amphetamine, Adderall products, and that's probably dose dependent, but it's close to one out of 500 people.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Now that we're finally looking at that a little more closely, because for years the ADHD experts have said, yeah, it's really rare, let's not look at it at all, let's not pay attention, move along, you know, don't look. With amphetamine, Adderall products, and that's probably dose dependent, but it's close to one out of 500 people.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And what's, I'm going off on a tangent here, but I'll keep following it because it's an important tangent. It's only one out of 500 people. That's uncommon. But this is a really bad condition because so amphetamine induced psychosis is a schizophrenic like picture. Usually someone is really paranoid, really worried that their friends are manipulating them or the police are spying on them.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And what's, I'm going off on a tangent here, but I'll keep following it because it's an important tangent. It's only one out of 500 people. That's uncommon. But this is a really bad condition because so amphetamine induced psychosis is a schizophrenic like picture. Usually someone is really paranoid, really worried that their friends are manipulating them or the police are spying on them.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And what's, I'm going off on a tangent here, but I'll keep following it because it's an important tangent. It's only one out of 500 people. That's uncommon. But this is a really bad condition because so amphetamine induced psychosis is a schizophrenic like picture. Usually someone is really paranoid, really worried that their friends are manipulating them or the police are spying on them.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, if you drink too much alcohol, you can be batshit crazy, that's a highly technical term there. You can be out of touch with reality. You can be hallucinating. You can be saying all sorts of nasty things. But if it's alcohol-induced, you fall asleep at the end of that night, you wake up the next morning, you may feel horrible at the hangover, you're not hallucinating.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, if you drink too much alcohol, you can be batshit crazy, that's a highly technical term there. You can be out of touch with reality. You can be hallucinating. You can be saying all sorts of nasty things. But if it's alcohol-induced, you fall asleep at the end of that night, you wake up the next morning, you may feel horrible at the hangover, you're not hallucinating.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, if you drink too much alcohol, you can be batshit crazy, that's a highly technical term there. You can be out of touch with reality. You can be hallucinating. You can be saying all sorts of nasty things. But if it's alcohol-induced, you fall asleep at the end of that night, you wake up the next morning, you may feel horrible at the hangover, you're not hallucinating.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You're not psychotic anymore. Hopefully you're regretting what you did, probably not remembering much of what you did. People will let you know. With amphetamine...

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You're not psychotic anymore. Hopefully you're regretting what you did, probably not remembering much of what you did. People will let you know. With amphetamine...