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Dr. John Kruse

👤 Person
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You're not psychotic anymore. Hopefully you're regretting what you did, probably not remembering much of what you did. People will let you know. With amphetamine...

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Induced psychosis, on the other hand, classically and characteristically and what I've seen clinically, it continues for days, weeks, or months after stopping the medication, which means we've changed someone's brain and we don't have lots and lots of data and it's actually only come to us because people are concerned about marijuana causing a similar picture.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Induced psychosis, on the other hand, classically and characteristically and what I've seen clinically, it continues for days, weeks, or months after stopping the medication, which means we've changed someone's brain and we don't have lots and lots of data and it's actually only come to us because people are concerned about marijuana causing a similar picture.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Induced psychosis, on the other hand, classically and characteristically and what I've seen clinically, it continues for days, weeks, or months after stopping the medication, which means we've changed someone's brain and we don't have lots and lots of data and it's actually only come to us because people are concerned about marijuana causing a similar picture.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So now we're studying this a little more. Well, with amphetamine-induced psychosis, about, and these are again rounding from different studies, about 20%, if you look 20 years out, about 20% of those people are in a permanent psychotic state still. So again, it's uncommon, but it's such a bad outcome that we really should be alerting people to it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So now we're studying this a little more. Well, with amphetamine-induced psychosis, about, and these are again rounding from different studies, about 20%, if you look 20 years out, about 20% of those people are in a permanent psychotic state still. So again, it's uncommon, but it's such a bad outcome that we really should be alerting people to it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So now we're studying this a little more. Well, with amphetamine-induced psychosis, about, and these are again rounding from different studies, about 20%, if you look 20 years out, about 20% of those people are in a permanent psychotic state still. So again, it's uncommon, but it's such a bad outcome that we really should be alerting people to it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I've been, I saw a much higher risk of this for I can get into it if we need a reasons in my population in San Francisco. But I've had people coming from all the most prominent ADHD clinics over the years who just moved to the area.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I've been, I saw a much higher risk of this for I can get into it if we need a reasons in my population in San Francisco. But I've had people coming from all the most prominent ADHD clinics over the years who just moved to the area.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I've been, I saw a much higher risk of this for I can get into it if we need a reasons in my population in San Francisco. But I've had people coming from all the most prominent ADHD clinics over the years who just moved to the area.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And when I'd say this, give this as my introduction to, you know, I'm happy to continue on this, but are you aware, to a person they said, no one ever told me that. Now maybe they have ADHD and weren't listening, but it's so uniformly consistent that they didn't hear or know that that was a side effect. And one in 500 isn't a trivially small number. No, it's not trivial.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And when I'd say this, give this as my introduction to, you know, I'm happy to continue on this, but are you aware, to a person they said, no one ever told me that. Now maybe they have ADHD and weren't listening, but it's so uniformly consistent that they didn't hear or know that that was a side effect. And one in 500 isn't a trivially small number. No, it's not trivial.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And when I'd say this, give this as my introduction to, you know, I'm happy to continue on this, but are you aware, to a person they said, no one ever told me that. Now maybe they have ADHD and weren't listening, but it's so uniformly consistent that they didn't hear or know that that was a side effect. And one in 500 isn't a trivially small number. No, it's not trivial.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I mean, why I got alerted to it is my rate in San Francisco is actually higher than one out of 100. And so I'll go into, I think, a couple different reasons. One is I worked with a lot of HIV positive men. And we know HIV, particularly in the days before we had effective antivirals, is a virus that goes to the brain and affect, you know, there's a, HIV-induced dementia.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I mean, why I got alerted to it is my rate in San Francisco is actually higher than one out of 100. And so I'll go into, I think, a couple different reasons. One is I worked with a lot of HIV positive men. And we know HIV, particularly in the days before we had effective antivirals, is a virus that goes to the brain and affect, you know, there's a, HIV-induced dementia.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And I mean, why I got alerted to it is my rate in San Francisco is actually higher than one out of 100. And so I'll go into, I think, a couple different reasons. One is I worked with a lot of HIV positive men. And we know HIV, particularly in the days before we had effective antivirals, is a virus that goes to the brain and affect, you know, there's a, HIV-induced dementia.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So probably some of these people had brains that were compromised because of that and were vulnerable. Two, a high incidence of methamphetamine. So methamphetamine, street speed, is a chemically different molecule than amphetamine. It has an extra methyl group, and an extra methyl group can mean a lot.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So probably some of these people had brains that were compromised because of that and were vulnerable. Two, a high incidence of methamphetamine. So methamphetamine, street speed, is a chemically different molecule than amphetamine. It has an extra methyl group, and an extra methyl group can mean a lot.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So probably some of these people had brains that were compromised because of that and were vulnerable. Two, a high incidence of methamphetamine. So methamphetamine, street speed, is a chemically different molecule than amphetamine. It has an extra methyl group, and an extra methyl group can mean a lot.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So it's a cousin, but methamphetamine, we know, has higher rates of psychosis, higher rates of addiction. This tends to be more rewarding. But Again, in that population, and many of them would hide that history from me, but I think that the very first person I had with amphetamine-induced psychosis, a guy in his 40s, HIV positive for years. This was back in early, mid-90s.