Dr. John Kruse

And if the app approach doesn't work, the next level up is there are all sorts of companies making lock boxes and physical devices where you can lock yourself out of your device for certain hours of the day. And I think that's a good idea for lots of people.

And if the app approach doesn't work, the next level up is there are all sorts of companies making lock boxes and physical devices where you can lock yourself out of your device for certain hours of the day. And I think that's a good idea for lots of people.

So guanfacine and a related drug called clonidine, which can be confused with Klonopin and others. So clonidine and guanfacine are both alpha-2 agonists. So they work on a subset of the norepinephrine system. They're both originally antihypertensive for lowering blood pressure. And it was actually studies first in clonidine that suggested this could be helpful with people with ADHD.

So guanfacine and a related drug called clonidine, which can be confused with Klonopin and others. So clonidine and guanfacine are both alpha-2 agonists. So they work on a subset of the norepinephrine system. They're both originally antihypertensive for lowering blood pressure. And it was actually studies first in clonidine that suggested this could be helpful with people with ADHD.

So guanfacine and a related drug called clonidine, which can be confused with Klonopin and others. So clonidine and guanfacine are both alpha-2 agonists. So they work on a subset of the norepinephrine system. They're both originally antihypertensive for lowering blood pressure. And it was actually studies first in clonidine that suggested this could be helpful with people with ADHD.

And I think it was just a serendipitous initial discovery. It wasn't seeking out its mode of action to see if that really worked. One difference between the two of them is clonidine jumps off the norepinephrine alpha-2 receptor really quickly. And for people who skip a dose with their blood pressure medication or stop abruptly, it's not uncommon to have rebound hypertension.

And I think it was just a serendipitous initial discovery. It wasn't seeking out its mode of action to see if that really worked. One difference between the two of them is clonidine jumps off the norepinephrine alpha-2 receptor really quickly. And for people who skip a dose with their blood pressure medication or stop abruptly, it's not uncommon to have rebound hypertension.

And I think it was just a serendipitous initial discovery. It wasn't seeking out its mode of action to see if that really worked. One difference between the two of them is clonidine jumps off the norepinephrine alpha-2 receptor really quickly. And for people who skip a dose with their blood pressure medication or stop abruptly, it's not uncommon to have rebound hypertension.

And not to smile, but way higher than what you're being originally treated for to dangerous levels. guanfacine leaves the receptors more slowly and there have been formal studies trying to see if this is a problem or issue there.

And not to smile, but way higher than what you're being originally treated for to dangerous levels. guanfacine leaves the receptors more slowly and there have been formal studies trying to see if this is a problem or issue there.

And not to smile, but way higher than what you're being originally treated for to dangerous levels. guanfacine leaves the receptors more slowly and there have been formal studies trying to see if this is a problem or issue there.

And particularly given that people with ADHD forget their medication or run out and don't fill it in time or just don't remember to take it, the rebound hypertension does not seem to be nearly as common with guanfacine and that's part of why the research has moved more towards the guanfacine. So there's extensive work by, I'm going to blank on her, Amy Arden, she's at Yale. Oh, Arnston.

And particularly given that people with ADHD forget their medication or run out and don't fill it in time or just don't remember to take it, the rebound hypertension does not seem to be nearly as common with guanfacine and that's part of why the research has moved more towards the guanfacine. So there's extensive work by, I'm going to blank on her, Amy Arden, she's at Yale. Oh, Arnston.

And particularly given that people with ADHD forget their medication or run out and don't fill it in time or just don't remember to take it, the rebound hypertension does not seem to be nearly as common with guanfacine and that's part of why the research has moved more towards the guanfacine. So there's extensive work by, I'm going to blank on her, Amy Arden, she's at Yale. Oh, Arnston.

Arnston, thank you. And her lab and related labs have shown that quamphicine's effects seem to deal with strengthening synaptic connections in prefrontal circuitry. So unlike most of our drugs that are just boosting norepinephrine and or quamphicine, dopamine and work quickly. And I'll throw in this because we didn't really touch this.

Arnston, thank you. And her lab and related labs have shown that quamphicine's effects seem to deal with strengthening synaptic connections in prefrontal circuitry. So unlike most of our drugs that are just boosting norepinephrine and or quamphicine, dopamine and work quickly. And I'll throw in this because we didn't really touch this.

Arnston, thank you. And her lab and related labs have shown that quamphicine's effects seem to deal with strengthening synaptic connections in prefrontal circuitry. So unlike most of our drugs that are just boosting norepinephrine and or quamphicine, dopamine and work quickly. And I'll throw in this because we didn't really touch this.

Most of the ADHD experts still say stimulants, amphetamine, Ritalin work quickly immediately because they boost dopamine right away. And our drugs like Stratera, which is atomoxetine or Cymbalta or Welbutrin, work slowly for ADHD because they're antidepressants and antidepressants work slowly. There's still people saying this.

Most of the ADHD experts still say stimulants, amphetamine, Ritalin work quickly immediately because they boost dopamine right away. And our drugs like Stratera, which is atomoxetine or Cymbalta or Welbutrin, work slowly for ADHD because they're antidepressants and antidepressants work slowly. There's still people saying this.

Most of the ADHD experts still say stimulants, amphetamine, Ritalin work quickly immediately because they boost dopamine right away. And our drugs like Stratera, which is atomoxetine or Cymbalta or Welbutrin, work slowly for ADHD because they're antidepressants and antidepressants work slowly. There's still people saying this.