Dr. John Kruse

And for 25 years, I've been saying this is just wrong from, one, a basic neuroscience point of view and wrong from don't you ever talk or listen to patients. So neuroscience view. How quickly does dopamine reuptake get blocked by Welbutrin or by Adamoxetine, Stratera, or by Cymbalta? Within minutes to hours of taking it.

And for 25 years, I've been saying this is just wrong from, one, a basic neuroscience point of view and wrong from don't you ever talk or listen to patients. So neuroscience view. How quickly does dopamine reuptake get blocked by Welbutrin or by Adamoxetine, Stratera, or by Cymbalta? Within minutes to hours of taking it.

And for 25 years, I've been saying this is just wrong from, one, a basic neuroscience point of view and wrong from don't you ever talk or listen to patients. So neuroscience view. How quickly does dopamine reuptake get blocked by Welbutrin or by Adamoxetine, Stratera, or by Cymbalta? Within minutes to hours of taking it.

So you would expect, if you're boosting norepinephrine or dopamine availability right away, you should see effects right away. And if you ask patients who these drugs work for, and they don't work for anybody, all the ones I've worked with say, It worked just like the stint. I could tell. I took it and I walked out of your office. One guy I have who loves Cymbalta...

So you would expect, if you're boosting norepinephrine or dopamine availability right away, you should see effects right away. And if you ask patients who these drugs work for, and they don't work for anybody, all the ones I've worked with say, It worked just like the stint. I could tell. I took it and I walked out of your office. One guy I have who loves Cymbalta...

So you would expect, if you're boosting norepinephrine or dopamine availability right away, you should see effects right away. And if you ask patients who these drugs work for, and they don't work for anybody, all the ones I've worked with say, It worked just like the stint. I could tell. I took it and I walked out of your office. One guy I have who loves Cymbalta...

said, I took it in your office, and I wasn't sure it was working, and I got downtown to work 15, 20, maybe a half hour later, and there was this guy coming at me on a skateboard on the sidewalk. And I know in my normal ADD state, I would have just been flooded and not be able to process, and I could just step out of the way. So it worked that quickly and dramatically. So that's the aside.

said, I took it in your office, and I wasn't sure it was working, and I got downtown to work 15, 20, maybe a half hour later, and there was this guy coming at me on a skateboard on the sidewalk. And I know in my normal ADD state, I would have just been flooded and not be able to process, and I could just step out of the way. So it worked that quickly and dramatically. So that's the aside.

said, I took it in your office, and I wasn't sure it was working, and I got downtown to work 15, 20, maybe a half hour later, and there was this guy coming at me on a skateboard on the sidewalk. And I know in my normal ADD state, I would have just been flooded and not be able to process, and I could just step out of the way. So it worked that quickly and dramatically. So that's the aside.

So jumping back, guanfacine seems to work slowly. So the synaptic strengthening building, and it seems to be the alpha-2 receptors that are on neurons that receive glutamate as their primary input. The alpha-2 receptor is modulating how glutamate is actually working, and it's actually the the NMDA glutamate receptors, not the more common in the brain AMPA glutamate receptors.

So jumping back, guanfacine seems to work slowly. So the synaptic strengthening building, and it seems to be the alpha-2 receptors that are on neurons that receive glutamate as their primary input. The alpha-2 receptor is modulating how glutamate is actually working, and it's actually the the NMDA glutamate receptors, not the more common in the brain AMPA glutamate receptors.

So jumping back, guanfacine seems to work slowly. So the synaptic strengthening building, and it seems to be the alpha-2 receptors that are on neurons that receive glutamate as their primary input. The alpha-2 receptor is modulating how glutamate is actually working, and it's actually the the NMDA glutamate receptors, not the more common in the brain AMPA glutamate receptors.

Yeah, so most often it takes two, three, four weeks. And because of it, I mean, with the stimulants, you see effects right away. It's reinforcing, and stimulants often... in addition to having effects on concentration, attention, other, you know, do boost energy for most people, do boost mood for most people. And can improve sleep, if they're not taken too close to sleep, yeah.

Yeah, so most often it takes two, three, four weeks. And because of it, I mean, with the stimulants, you see effects right away. It's reinforcing, and stimulants often... in addition to having effects on concentration, attention, other, you know, do boost energy for most people, do boost mood for most people. And can improve sleep, if they're not taken too close to sleep, yeah.

Yeah, so most often it takes two, three, four weeks. And because of it, I mean, with the stimulants, you see effects right away. It's reinforcing, and stimulants often... in addition to having effects on concentration, attention, other, you know, do boost energy for most people, do boost mood for most people. And can improve sleep, if they're not taken too close to sleep, yeah.

Guanfacine's most common side effect tends to be sedating. So most people take it at nighttime, which is like, why are you taking a sedating nighttime medication for your ADHD? It's because it helps, it works slowly, indirectly.

Guanfacine's most common side effect tends to be sedating. So most people take it at nighttime, which is like, why are you taking a sedating nighttime medication for your ADHD? It's because it helps, it works slowly, indirectly.

Guanfacine's most common side effect tends to be sedating. So most people take it at nighttime, which is like, why are you taking a sedating nighttime medication for your ADHD? It's because it helps, it works slowly, indirectly.

So Intuniv, the brand name extended release guanfacine, was approved in kids, because again, most of the research on ADHD is still in kids, for treating ADHD as a solo agent. It clearly works in adults as well. And even before Intuniv was approved, there were a handful of studies with either immediate-release guanfacine or extended-release guanfacine.

So Intuniv, the brand name extended release guanfacine, was approved in kids, because again, most of the research on ADHD is still in kids, for treating ADHD as a solo agent. It clearly works in adults as well. And even before Intuniv was approved, there were a handful of studies with either immediate-release guanfacine or extended-release guanfacine.