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Dr. John Kruse

👤 Speaker
915 total appearances

Appearances Over Time

Podcast Appearances

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Even though it's the non-stimulant stimulant, and I'd say most people do experience, you know, I feel more alert or awake or better, but I don't feel revved up, about 10% to 15% of people that I've worked with and others have written about it, so I don't think it's unique, will feel revved up when they take it the first few times.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And invariably, the people I've worked with have said, this feels like bad speed, including people who haven't too, who never even took speed. So I don't know why they came up. I mean, it's just weird that people come up with the same terms. But it's, I mean, my interpretation is that for some people,

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And invariably, the people I've worked with have said, this feels like bad speed, including people who haven't too, who never even took speed. So I don't know why they came up. I mean, it's just weird that people come up with the same terms. But it's, I mean, my interpretation is that for some people,

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And invariably, the people I've worked with have said, this feels like bad speed, including people who haven't too, who never even took speed. So I don't know why they came up. I mean, it's just weird that people come up with the same terms. But it's, I mean, my interpretation is that for some people,

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

this novel substance primarily maybe attacking into the orexin system is serving as a signal, kind of like a panic attack does, that there's something weird, something different, we're being revved up, and that it's, I think, secondarily triggering the sympathetic system. Because for most of those people, within a few trials, within a few days, they no longer had that over-revved effect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

this novel substance primarily maybe attacking into the orexin system is serving as a signal, kind of like a panic attack does, that there's something weird, something different, we're being revved up, and that it's, I think, secondarily triggering the sympathetic system. Because for most of those people, within a few trials, within a few days, they no longer had that over-revved effect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

this novel substance primarily maybe attacking into the orexin system is serving as a signal, kind of like a panic attack does, that there's something weird, something different, we're being revved up, and that it's, I think, secondarily triggering the sympathetic system. Because for most of those people, within a few trials, within a few days, they no longer had that over-revved effect.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, the important piece for... Alerting people to that is if they're expecting taking this, I'm not going to feel over-aroused and over-agitated. And they do, then they're even less prepared and more freaked out.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, the important piece for... Alerting people to that is if they're expecting taking this, I'm not going to feel over-aroused and over-agitated. And they do, then they're even less prepared and more freaked out.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

And again, the important piece for... Alerting people to that is if they're expecting taking this, I'm not going to feel over-aroused and over-agitated. And they do, then they're even less prepared and more freaked out.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, it is a – controlled substance because some people are worried about the potential. And there was a woman Olympic athlete 20, 15 years ago who was and said she had narcolepsy. I don't know, but was disqualified from the Olympics because of it. Whether it has any real performance-enhancing effects is not clear.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, it is a – controlled substance because some people are worried about the potential. And there was a woman Olympic athlete 20, 15 years ago who was and said she had narcolepsy. I don't know, but was disqualified from the Olympics because of it. Whether it has any real performance-enhancing effects is not clear.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

I mean, it is a – controlled substance because some people are worried about the potential. And there was a woman Olympic athlete 20, 15 years ago who was and said she had narcolepsy. I don't know, but was disqualified from the Olympics because of it. Whether it has any real performance-enhancing effects is not clear.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You know, it was available in France for a decade, at least, before it came to the U.S., and they didn't see any rates of substance abuse or problems. I mean, it clearly does not have the—on any tests or animal studies— the propensity that the amphetamines do. And I'd say it's to me not to conclude its subject, whether there's any potential for addiction with it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You know, it was available in France for a decade, at least, before it came to the U.S., and they didn't see any rates of substance abuse or problems. I mean, it clearly does not have the—on any tests or animal studies— the propensity that the amphetamines do. And I'd say it's to me not to conclude its subject, whether there's any potential for addiction with it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

You know, it was available in France for a decade, at least, before it came to the U.S., and they didn't see any rates of substance abuse or problems. I mean, it clearly does not have the—on any tests or animal studies— the propensity that the amphetamines do. And I'd say it's to me not to conclude its subject, whether there's any potential for addiction with it.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Maybe I'll start with that. So for decades, particularly starting with kids, the dogma has been taking breaks from stimulants is a good idea because it will decrease the likelihood of developing addictions, it will decrease tolerance, and... Not a lot of rigorous research, but one of the known side effects of stimulants for kids is growth suppression.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Maybe I'll start with that. So for decades, particularly starting with kids, the dogma has been taking breaks from stimulants is a good idea because it will decrease the likelihood of developing addictions, it will decrease tolerance, and... Not a lot of rigorous research, but one of the known side effects of stimulants for kids is growth suppression.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

Maybe I'll start with that. So for decades, particularly starting with kids, the dogma has been taking breaks from stimulants is a good idea because it will decrease the likelihood of developing addictions, it will decrease tolerance, and... Not a lot of rigorous research, but one of the known side effects of stimulants for kids is growth suppression.

Huberman Lab
Improve Focus with Behavioral Tools & Medication for ADHD | Dr. John Kruse

So height winds up being about two centimeters, not big, but measurably and consistently found there for kids who are routinely on the stimulants for their growth years. And taking breaks that last for several months, like taking it off during the summer, result in overcoming that decrement in height.